Immunology 1

Question 1

What region of Ig forms antigen binding site

Answer 1

Variable regions of light and heavy chains

Question 2

Location of Kappa light chain genes

Answer 2

Ch 2

Question 3

Location of Lambda light chain genes

Answer 3

Ch 22

Question 4

Location of Heavy chain genes

Answer 4

Ch 14

Question 5

What part is seen in heavy chains only

Answer 5

Diversity (D)

Question 6

What rearranges first

Answer 6

Variable

Question 7

Mature Bcells coexpress

Answer 7

IgM and IgD

Question 8

Idiotope =

Answer 8

epitope formed by variable end of Ig molecule

Question 9

IgG that cannot cross placenta

Answer 9

IgG2

Question 10

IgG that cannot activate complement

Answer 10

IgG4

Question 11

TCR genes located on

Answer 11

Ch 7

Question 12

normal CD4/CD8 ratio

Answer 12

2:1

Question 13

Function of TdT enzyme

Answer 13

randomly add nucleotides to create additional variablility of TCRs

Question 14

Locations of gamma delta T cells

Answer 14

mucosa and skin (<5% of all Tcells)

Question 15

CD16 is

Answer 15

receptor for Fc protion on gamma heavy chains

Question 16

NK cells secrete what and moderate what

Answer 16

Secrete IFN-gamma to moderate antigen-dependent cellular cytotoxicity

Question 17

MHC class II is found on

Answer 17

Bcells, macrophages, activated Tcells (all antigen-presenting cells)

Question 18

Interleukin secreted by antigen-presenting cells

Answer 18

IL-1

Question 19

IL-4 is secreted by ___ and stimulates _____

Answer 19

Th2 cells

Production of IgE

Question 20

Opsonization

Answer 20

attachment of C3b to surface

Question 21

Anaphylatoxins are ______ and do what?

Answer 21

C3a, C5a
promote histamine release from basophils
increase vascular permeability and vasodilation

Question 22

Ig’s activating classic complement pathway

Answer 22

IgM, IgG1, IgG2, IgG3

Question 23

Fc poriton of Ig interacts with ____ to initiate classical pathway

Answer 23

C1q

Question 24

2 important convertases of classical pathway

Answer 24

C4b2b, C4b2b3b

Question 25

How is alternate pathway activated

Answer 25

cell walls, venom, endotoxin, complexed IgA

Question 26

Normally, C3b is rapidly inactivated by

Answer 26

Factor 1

Question 27

Location of MHC genes

Answer 27

Ch6p

Question 28

other genes near MHC

Answer 28

hereditary hemochromatosis, 21-hydroxylase, TNF

Question 29

HLA class I located

Answer 29

all nucleated cells and plts

Question 30

Structure of HLA class I

Answer 30

single chain similar to Ig heavy chain + transmembrane domain
Associates with beta-2-microglobulin

Question 31

Which HLA important against viruses

Answer 31

HLA class 1