Immunology 1 Flashcards
What region of Ig forms antigen binding site
Variable regions of light and heavy chains
Location of Kappa light chain genes
Ch 2
Location of Lambda light chain genes
Ch 22
Location of Heavy chain genes
Ch 14
What part is seen in heavy chains only
Diversity (D)
What rearranges first
Variable
Mature Bcells coexpress
IgM and IgD
Idiotope =
epitope formed by variable end of Ig molecule
IgG that cannot cross placenta
IgG2
IgG that cannot activate complement
IgG4
TCR genes located on
Ch 7
normal CD4/CD8 ratio
2:1
Function of TdT enzyme
randomly add nucleotides to create additional variablility of TCRs
Locations of gamma delta T cells
mucosa and skin (<5% of all Tcells)
CD16 is
receptor for Fc protion on gamma heavy chains
NK cells secrete what and moderate what
Secrete IFN-gamma to moderate antigen-dependent cellular cytotoxicity
MHC class II is found on
Bcells, macrophages, activated Tcells (all antigen-presenting cells)
Interleukin secreted by antigen-presenting cells
IL-1
IL-4 is secreted by ___ and stimulates _____
Th2 cells
Production of IgE
Opsonization
attachment of C3b to surface
Anaphylatoxins are ______ and do what?
C3a, C5a
promote histamine release from basophils
increase vascular permeability and vasodilation
Ig’s activating classic complement pathway
IgM, IgG1, IgG2, IgG3
Fc poriton of Ig interacts with ____ to initiate classical pathway
C1q
2 important convertases of classical pathway
C4b2b, C4b2b3b
How is alternate pathway activated
cell walls, venom, endotoxin, complexed IgA
Normally, C3b is rapidly inactivated by
Factor 1
Location of MHC genes
Ch6p
other genes near MHC
hereditary hemochromatosis, 21-hydroxylase, TNF
HLA class I located
all nucleated cells and plts
Structure of HLA class I
single chain similar to Ig heavy chain + transmembrane domain
Associates with beta-2-microglobulin
Which HLA important against viruses
HLA class 1
