Teratogens High Yield Flashcards
ACE inhibitors
renal Damage
Alkylating agents
absence of digits
Aminoglycosides
CN VIII toxicity
Carbamazepine
Facial dysmorphism
Neural tube defects
Phalynx/ fingernail hypoplasia
Diethylstilbestrol (DES)
vaginal clear cell carcinoma
Folate antagonists
Neural tube defects
Isotretinoin
Multiple severe birth defects
Lithium
ebstein anomaly (atrialized right ventricle)
Aethimazole
Aplasia cutis congenita
Phenytoin
Fetal hydantoin syndrome (cleft palate, cardiac defects, phalynx/ fingernail hypoplasia)
Tetracyclines
Discolored teeth
Thalidomide
Limb defects
Valproate
neural tube defects
Warfarin
Bone deformities
Fetal hemorrhage
Abortion
Ophthalmologic abnormalites
Alcohol
intellectual disability (FAS)
Cocaine
Placental abruption and abnormal fetal growth
Smoking
Low birth weight, preterm labor, placental abruptions
Iodine (lack or excess)
Cretinism
Maternal diabetes
caudal regression syndrome (anal atresia and sirenomelia)
Congeital heart defects
Neural tube defects
Vit A (excess)
extremely high risk for spontaneous abortions and birth defects (cleft palate, cardiac)
X- rays
microcephaly
intellectual disability
What is the mechanism of FAS?
failure of cell migration
2 findings in the most severe cases of FAS?
Heart Lung Fistulas
Holoprosencephaly
