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Step 1 Review > Immunosuppressants High Yield > Flashcards

Immunosuppressants High Yield Flashcards

1
Q

“blocks T cell activation by preventing I:-2 transcription”

A

Cyclosporine and Tacrolimus

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2
Q

AE of cyclosporine?

A

Nephrotoxicity

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3
Q

“inhibits mTOR to block T cell activation and B cell differentiation by preventing response to IL-2”

A

Sirolimus

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4
Q

What are the main AE of sirolimus?

A

Anemia, thrombocytopenia, leukopenia, insulin resistance

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5
Q

“monoclonal antibodies that block IL-2 receptor”

A

Daclizumab and Basiliximab

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6
Q

What is sirolimus used for?

A

Kidney transplant rejection prophylaxis

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7
Q

What is daclizumab/ baslizimab used for?

A

Kidney transplant rejection prophylaxis

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8
Q

“antimetabolite of 6-MP leading to inibition of lymphocyte proliferation by blocking nucleotide synthesis”

A

Azathioprine

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9
Q

AE of Azathrioprine?

A

Pancytopenia

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10
Q

What can increase the toxicity of azathrioprine?

A

allopurinol (because it inhibits XO needed for 6-MP degredation)

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11
Q

“inhibits NF-kappa B to suppress both B and T cell function by decreasing suppression of cytokines”

A

Glucocorticoids

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12
Q

What immunosuppressant can be used to treat:

Psoriasis

A

Cyclosporine

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13
Q

What immunosuppressant can be used to treat:

Rheumatoid arthritis

A

Azathriopine

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14
Q

What immunosuppressant can be used to treat:

Crohn disease

A

Azathrioprine

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15
Q

What immunosuppressant can be used to treat:

Glomerulonephritis

A

Azathrioprine

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16
Q

What immunosuppressant can be used to treat

Transplant rejection prophylaxis

A

Cyclosporine, tacrolimus, Azathrioprine, glucocoricoids

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17
Q

What is Aldesleukin used for?

A

RCC

Metastatic carcinoma

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18
Q

What is epoitin alfa used to treat?

A

Anemia (it is EPO)

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19
Q

What is filgrastim?

A

G-CSF

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20
Q

What is filgrastim used for?

A

recovery of bone marrow

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21
Q

What is sargramostim?

A

GM- CSF

22
Q

What is sargramostim used for?

A

Recovery of bone marrow

23
Q

What is IFN alpha used to treat?

A

Hep B
Hep C
Kaposi sarcoma
Malignant melanoma

24
Q

What is IFN beta used to treat?

A

Multiple sclerosis

25
Q

What is IFN gamma used to treat?

A

Chronic granulomatous disease

26
Q

What is oprelvekin?

A

IL-11

27
Q

What is oprelvekin used to treat?

A

Thrombcytopenia

28
Q

What does alemtuzumab target?

A

CD52

29
Q

What is alemtuzumab used for?

A

CLL

30
Q

What does bevacizumab target?

A

VEGF

31
Q

What is bevacizumab used to treat?

A

Colorectal cancer

RCC

32
Q

What does cetuximab target?

A

EGFR

33
Q

What does cetuximab treat?

A

IV breast colorectal cancer

Head and neck cancer

34
Q

What does rituximab target?

A

CD 20

35
Q

What does rituximab treat?

A

B cell non hodgkin lymphoma
CLL
RA
ITP

36
Q

What does trastuzumab target?

A

HER2/neu

37
Q

What does trastuzumab treat?

A

Breast cancer

38
Q

What does adalimumab/ infliximab target?

A

soluble TNF- alpha

39
Q

What is the use of adalimumab/ infliximab?

A

IBS
RA
Anklyosing spondylitis
Psoriasis

40
Q

What does eculizumab target?

A

complement protein C5

41
Q

What does eculizumab treat?

A

paroxysmal nocturnal hemoglobiunuria

42
Q

What does Natalizumab target?

A

alpha4- integrin

43
Q

What does natalizumab treat?

A

Multiple sclerosis

Crohn disease

44
Q

Wat does abciximab taret?

A

platelet glycoproteins IIb/ IIIa

45
Q

What does denosumab target?

A

RANKL

46
Q

What is denosumab used to treat?

A

osteoporisis

47
Q

What does omalizumab target?

A

IgE

48
Q

What does omalizumab treat?

A

allergic asthma

(prevents IgE binding to Fc- epsilon-RI

49
Q

What does palivizumab target?

A

RSV F protein

50
Q

What does Palivizumab treat?

A

RSV prophylaxis for high risk infants

51
Q

What does ranibizumab target?

A

VEGF

52
Q

What does ranibizumab treat?

A

Neobascularization age related macular degeneration

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