Immunosuppressants High Yield

Question 1

“blocks T cell activation by preventing I:-2 transcription”

Answer 1

Cyclosporine and Tacrolimus

Question 2

AE of cyclosporine?

Answer 2

Nephrotoxicity

Question 3

“inhibits mTOR to block T cell activation and B cell differentiation by preventing response to IL-2”

Answer 3

Sirolimus

Question 4

What are the main AE of sirolimus?

Answer 4

Anemia, thrombocytopenia, leukopenia, insulin resistance

Question 5

“monoclonal antibodies that block IL-2 receptor”

Answer 5

Daclizumab and Basiliximab

Question 6

What is sirolimus used for?

Answer 6

Kidney transplant rejection prophylaxis

Question 7

What is daclizumab/ baslizimab used for?

Answer 7

Kidney transplant rejection prophylaxis

Question 8

“antimetabolite of 6-MP leading to inibition of lymphocyte proliferation by blocking nucleotide synthesis”

Answer 8

Azathioprine

Question 9

AE of Azathrioprine?

Answer 9

Pancytopenia

Question 10

What can increase the toxicity of azathrioprine?

Answer 10

allopurinol (because it inhibits XO needed for 6-MP degredation)

Question 11

“inhibits NF-kappa B to suppress both B and T cell function by decreasing suppression of cytokines”

Answer 11

Glucocorticoids

Question 12

What immunosuppressant can be used to treat:

Psoriasis

Answer 12

Cyclosporine

Question 13

What immunosuppressant can be used to treat:

Rheumatoid arthritis

Answer 13

Azathriopine

Question 14

What immunosuppressant can be used to treat:

Crohn disease

Answer 14

Azathrioprine

Question 15

What immunosuppressant can be used to treat:

Glomerulonephritis

Answer 15

Azathrioprine

Question 16

What immunosuppressant can be used to treat

Transplant rejection prophylaxis

Answer 16

Cyclosporine, tacrolimus, Azathrioprine, glucocoricoids

Question 17

What is Aldesleukin used for?

Answer 17

RCC

Metastatic carcinoma

Question 18

What is epoitin alfa used to treat?

Answer 18

Anemia (it is EPO)

Question 19

What is filgrastim?

Answer 19

G-CSF

Question 20

What is filgrastim used for?

Answer 20

recovery of bone marrow

Question 21

What is sargramostim?

Answer 21

GM- CSF

Question 22

What is sargramostim used for?

Answer 22

Recovery of bone marrow

Question 23

What is IFN alpha used to treat?

Answer 23

Hep B
Hep C
Kaposi sarcoma
Malignant melanoma

Question 24

What is IFN beta used to treat?

Answer 24

Multiple sclerosis

Question 25

What is IFN gamma used to treat?

Answer 25

Chronic granulomatous disease

Question 26

What is oprelvekin?

Answer 26

IL-11

Question 27

What is oprelvekin used to treat?

Answer 27

Thrombcytopenia

Question 28

What does alemtuzumab target?

Answer 28

CD52

Question 29

What is alemtuzumab used for?

Answer 29

CLL

Question 30

What does bevacizumab target?

Answer 30

VEGF

Question 31

What is bevacizumab used to treat?

Answer 31

Colorectal cancer | RCC

Question 32

What does cetuximab target?

Answer 32

EGFR

Question 33

What does cetuximab treat?

Answer 33

IV breast colorectal cancer | Head and neck cancer

Question 34

What does rituximab target?

Answer 34

CD 20

Question 35

What does rituximab treat?

Answer 35

B cell non hodgkin lymphoma CLL RA ITP

Question 36

What does trastuzumab target?

Answer 36

HER2/neu

Question 37

What does trastuzumab treat?

Answer 37

Breast cancer

Question 38

What does adalimumab/ infliximab target?

Answer 38

soluble TNF- alpha

Question 39

What is the use of adalimumab/ infliximab?

Answer 39

IBS RA Anklyosing spondylitis Psoriasis

Question 40

What does eculizumab target?

Answer 40

complement protein C5

Question 41

What does eculizumab treat?

Answer 41

paroxysmal nocturnal hemoglobiunuria

Question 42

What does Natalizumab target?

Answer 42

alpha4- integrin

Question 43

What does natalizumab treat?

Answer 43

Multiple sclerosis Crohn disease

Question 44

Wat does abciximab taret?

Answer 44

platelet glycoproteins IIb/ IIIa

Question 45

What does denosumab target?

Answer 45

RANKL

Question 46

What is denosumab used to treat?

Answer 46

osteoporisis

Question 47

What does omalizumab target?

Answer 47

IgE

Question 48

What does omalizumab treat?

Answer 48

allergic asthma (prevents IgE binding to Fc- epsilon-RI

Question 49

What does palivizumab target?

Answer 49

RSV F protein

Question 50

What does Palivizumab treat?

Answer 50

RSV prophylaxis for high risk infants

Question 51

What does ranibizumab target?

Answer 51

VEGF

Question 52

What does ranibizumab treat?

Answer 52

Neobascularization age related macular degeneration