G Protein Linked Secondary Messengers Flashcards

1
Q

Alpha 1

A

Gq

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2
Q

alpha 2

A

Gi

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3
Q

Beta 1

A

Gs

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4
Q

Beta 2

A

Gs

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5
Q

M1

A

Gq

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6
Q

M2

A

Gi

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7
Q

M3

A

Gq

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8
Q

D1

A

Gs

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9
Q

D2

A

Gi

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10
Q

H1

A

Gq

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11
Q

H2

A

Gs

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12
Q

V1

A

Gq

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13
Q

V2

A

Gs

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14
Q

What is the mechanism of Gq?

A

Increase PHOSPHOLIPASE C–> increase DAG/ IP3–> Increased Ca

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15
Q

What is the mechanism of Gs?

A

Increase adenylate cyclase–> increase cAMP

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16
Q

What is the mechanism of Gi?

A

Decrease adenylate cyclase–> decrease cAMP

17
Q

What receptors are linked to Gq?

A

H1, alpha 1, V1, M1, M3

18
Q

What receptors are linked to Gs?

A

beta 1, beta 2, D1, H2, V2

19
Q

What receptors are linked to Gi?

A

M2, alpha 2, D2