Oncogenes and Tumor Suppressor Genes Flashcards by Erin Allmer

Q

Gene product? Associated Tumor?

BCR- ABL

A

Tyrosine Kinase

CML, ALL

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Q

Gene product? Associated Tumor?

BCL-2

A

Antiapoptotic molecule

Follicular and undifferentiated lymphomas

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Q

Gene product? Associated Tumor?

BRAF

A

Serine/ threonine kinase

Melanoma

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Q

Gene product? Associated Tumor?

c-kit

A

Cytokkine receptor

GIST (gastrointestinal stromal tumor)

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Q

Gene product? Associated Tumor?

c- myc

A

Transcription factor

Burkitt lymphoma

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Q

Gene product? Associated Tumor?

HER2/ neu

A

Tyrosine kinase

Breast, ovarian, and gastric carcinomas

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Q

Gene product? Associated Tumor?

L- myc

A

Transcription factor

Lung tumor

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Q

Gene product? Associated Tumor?

N- myc

A

Transcription factor

Neuroblastoma

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Q

Gene product? Associated Tumor?

RAS

A

GTPase

Colon cancer lung cancer, pancreatic cancer

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Q

Gene product? Associated Tumor?

RET

A

Tyrosine kinase

MEN 2A/ 2B

Medullary thyroid cancer

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Q

Gene product? Associated Tumor?

APC

A

No associated product

Colorectal cancer

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Q

Gene product? Associated Tumor?

BRAC1/ BRCA2

A

DNA repair protein

Breast cancer/ Ovarian cancer

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Q

Gene product? Associated Tumor?

DCC

A

Deleted in colon cancer (tumor suppressor gene)

Colon cancer

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Q

Gene product? Associated Tumor?

DPC4/ SMAD4

A

Deleted in pancreased cancer (tumor suppressor gene)

Pancreatic cancer

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Q

Gene product? Associated Tumor?

MEN1

A

Menin

MEN1

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Q

Gene product? Associated Tumor?

NF1

A

Ras GTPase activating protein (neurofibromin)

NF1

Q

Gene product? Associated Tumor?

NF2

A

Merlin protein

NF2

Q

Gene product? Associated Tumor?

p16

A

cyclin dependant kinase inhibitor 2A

Melanoma

Q

Gene product? Associated Tumor?

p53

A

Transcription factor for p21, blocks G1–> S

most human cancers, Li- fraumeni syndrome

Q

Gene product? Associated Tumor?

PTEN

A

seen in breast cancer, prostate cancer, and endometrial cancer

Q

Gene product? Associated Tumor?

Rb

A

inhibits E2F; blocks G1–> S

retinoblastoma, osteosarcoma

Q

Gene product? Associated Tumor?

TSC1

A

Hamartin protein (tumor suppressor)

tuberous sclerosis

Q

Gene product? Associated Tumor?

TSC2

A

Tuberin protein (tumor suppressor)

Tuberous sclerosis

Q

Gene product? Associated Tumor?

VHL

A

Inhibits hypoxia inducible factor 1a

VHL disease, RCC

Gene product? Associated Tumor? WT1/ WT2

Tumor suppressor gene wilms tumor (nephroblastoma)