Micro 2 High Yield Flashcards
Which neisseria is intracellular?
N. gonorroeae
Which neisseria ferments maltose?
N. meningococci
What is the treatment for N. gonorrhea?
Ceftriaxone ( + azithromycin or doxycycline)
What is the treatment for N. meningococci?
Ceftriaxone or penicillin G
What type of deficiency leads to increased risk of infection with N. meningococci?
Deficiency in C5- C8
T/F: H. flu can only be grown on chocolate agar plates
False…it can also grow on a regular plate with S. aureus due to the beta hemolysis
How is mucosal H. flu treated?
Amoxicillin +/- clavulanate
How is H. flu meningitis treated?
Ceftriaxone
Which vaccine has a dipherthia toxic conjugation?
H. flue
What 2 things does Legionella need in order to grow?
Fe and Cysteine
How is legionella transmitted?
Aerosol transmission from environmental water source
How does legionella present in immunoCOMPROMISED hosts?
Legionnaires disease–> Pneumonia + GI + CNS symptoms
What are 2 risk factors for legionella?
Smoking
Alcoholics
What is the treatment for legionella?
Fluoroquinolone
What is a physical exam finding indicative of pseudomonas aeruginosa?
Fruity odor
How does EPEC infections cause disease?
E. coli adhere to apical surfaces, flatten villi and prevent reabsorption
Possible complications of EHEC?
HUS! Reactive arthritis
What risk factors are associated with klebsiella infection?
Alcoholics
Diabetics
“currant jelly sputum”
Klebsiella lobar pneumonia
What gram (-) rod likes to grow at 42 C?
Campylobacter jejuni
What are common complications of Campylobacter infections?
reactive arthritis
guillain barre syndrome
Describe the infectious dose of C. jejuni? Shigella?
Very LOW for both
What are the immune cells seen in Salmonella typhi infection?
Monocytes
What are the immune cells seen in salmonella spp and Shigella?
PMNs
T/F: antibiotics shorten the course of a salmonella infection?
FALSE–> Prolong infection
What receptor does V. cholerae enterotoxin permanently activate?
Gs–> increase cAMP
Are yersinia enterocolitic motile? or nonmotile?
They are motile at 25C and nonmotile at 37C
What type of environment (acidic or alkaline) does H. pylori create?
Alkaline (urease +)
How is treponemia usually visualized?
Dark field microscopy
Name the 3 spirochetes:
Borrelia
Leptospira
Treponema
How does leptospira typically present?
Influenza with GI symptoms
How is borrelia burgdorferi transmitted?
Ixodes deer tick
What are the 3 main initial symptoms of lyme disease?
1- erythema chronicum migrans
2- Flu like symptoms
3- facial nerve palsy
What are the 4 main later symptoms of lyme disease?
1- monoarthritis
2- migratory polyarthritis
Cardiac (AV nodal block)
Neurologic
How does primary syphilis present?
Painless chancre
What are the symptoms of secondary syphilis?
1- maculopapular rash
2- condylomata lata
How is a syphilis diagnosis made in primary stage?
Dark field or VDRL
What are the signs of congenital syphilis?
1- facial abnormalities 2- snuffles 3- saddle nose 4- notched teeth, mulberry molarss 5- short maxilla 6- saber shins 7- CN VIII deafness
What are the symptoms of tertiary syphilis?
1- gummas
2- aortitiss vasa casorum destruction)
3- neurosyphilis (tabes dorsalis)
4- Argyll roberston
What can give a VDRL false positive?
Viral infection
Drugs
Rheumatic fever
Lupus and leprosy
“pleomorphic gram variable rod involved in bacterial vaginosis”
Gardnerella vaginalis
What are the signs and symptoms of gardnerella vaginalis?
Fishy smell
Clue cells
How is gardnerella vaginalis treated?
Metronidazole
Clindamycin
Describe the rash seen in RMSF (Rickettsia rickettsii)?
Starts at wrists then spreads out, sparing palms and soles
Describe the rash of typhus (R. typhi and R. prowazekii)?
starts centrall then spreads out, sparing palms and soles
What is the classic triad of RMSF?
Headache, fever, rash (vasculitis)