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Step 1 Review > MSK Pharm > Flashcards

MSK Pharm Flashcards

1
Q

What is the mechanism of zileutron?

A

Inhibits lipoxygenase to inhibit leukotriene synthesis

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2
Q

What is the mechanism of montelukast and zafirlukast?

A

leukortiene receptor antagonists

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3
Q

What is the function of LTB4?

A

Neutrophil chemotactic

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4
Q

What is the function of PGI2?

A

inhibits platelet aggregation and promotes vasodilation

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5
Q

What are the 2 functions of acetaminophen?

A

1- antipyretic
2- analgesic

NOT AN ANTI INFLAMMATORY

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6
Q

How does acetominophen cause hepatic necrosis?

A

Its metabolite (NAPQI) depletes glutathione and forms toxic byproducts in the liver

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7
Q

What regenerates glutathione?

A

NAC

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8
Q

Effect of low does aspirin?

A

decrease platelet aggregation

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9
Q

Effect of intermediate dose aspirin?

A

Antpyretic and analgesic

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10
Q

Effect of high dose aspirin?

A

Anti-inflammtory

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11
Q

What is an AE of celecoxib?

A

increased risk of thrombosis

Sulfa allergy

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12
Q

What is used to close a PDA?

A

Indomethican–> COX inhibitor to decreased PGE2

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13
Q

What are the AEs of NSAIDS?

A

nephritis
gastric ulcers
renal ishcemia (because no vasodilation of afferent arterioles)

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14
Q

What is the mechanism of bisphosphonates?

A

inhibit osteoclast activity

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15
Q

What is a possible AE of bisphosphonates?

A

corrosive esophagitis, osteonecrosis of the jaw

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16
Q

What is teriparatide?

A

recombinant PTH analog to increase osteoblastic activity

17
Q

What is a possible AE for teriparatide?

A

Increased risk for osteosarcoma

18
Q

What is the mechanism of allopurinol?

A

Inhibits XO

19
Q

What is the mechanism of febuxostat?

A

inhibits XO

20
Q

What is the mechanism of pegloticase?

A

recombinant uricase that catalyzes metabolism of uric acid to allantoin

21
Q

What is the mecahnism of probenecid?

A

inhibits reabsorption of uric acid in PCT

22
Q

What is an AE of probenecid?

A

can precipitate uric acid calculi

23
Q

What drugs are used to treat gout acutely?

A

NSAIDS
Glucocorticoids
Colchicine

24
Q

How does cochicine work?

A

Binds to and stabilizes tubulin to inhibit microtubule polymerization (impairing neutrophil chemotaxis and degranulation)

25
Q

What is etanercept?

A

TNF alpha inhibitor

26
Q

What is infliximab/ adalimumab?

A

TNF alpha inhibitor

27
Q

What are the TNF alpha inhibitors used to treat?

A

RA, psoriasis, ankylosing spondylitis, IBD (infliximab)

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