Hem/ Onc High Yield

Question 1

Anisocytosis?

Answer 1

varying size RBC

Question 2

Life span of RBC?

Answer 2

120 days

Question 3

Piokilocytosis?

Answer 3

varing shape RBC

Question 4

What are platelets derived from?

Answer 4

megakaryocytes

Question 5

Life span of thrombocyte/ platlet?

Answer 5

8- 10 days

Question 6

What is the vWF receptor on platelets?

Answer 6

GpIb

Question 7

What is the fibrinogen receptor on platelets?

Answer 7

GpIIb/ IIIa

Question 8

Where are 1/3 of all platelets stored?

Answer 8

Spleen

Question 9

Name the 4 substances in the granules of platelets?

Answer 9

1- ADP
2- Ca2+
3- vWF
4- Fibrinogen

Question 10

“acute inflammatory response cell”

Answer 10

neutrophil

Question 11

What is in the specific granules of neutrophils? (4)

Answer 11

1- ALP
2- collagenase
3- lysozyme
4- lactoferrin

Question 12

What is in the azurophilic granules of neutrophils? (4)

Answer 12

1- proteinases
2- acid phosphatase
3- myeloperoxidase
4- Beta glucuronidase

Question 13

What are 4 MAJOR chemotactic agents for neutrophils?

Answer 13

1- C5a
2- IL-8
3- LTB4
4- Kallikrein
5- Platelet activating factor

Question 14

What do macrophages come from?

Answer 14

Monocytes! They differentiate once they enter tissue

Question 15

What cytokine activates macrophages?

Answer 15

Gamma interferon

Question 16

How do macrophages participate in Gram (-) septic shock?

Answer 16

Lipid A from LPS binds CD14 on macrophages to initiate septic shock

Question 17

Major function of eosinophils?

Answer 17

Helmith infections and phagocytose antigen- antibody complexes

Question 18

What are the 2 major substances of Eosinophils?

Answer 18

Histamine

Major Basic Protien

Question 19

Which cells mediate allergic reactions?

Answer 19

Basophils, eosinophils and mast cells

Question 20

What are the 2 major substances of basophils?

Answer 20

Heparin

Histamine

Question 21

Basophelia is a sign for what type of cancer?

Answer 21

CML

Question 22

What causes mast cell degranulation?

Answer 22

Cross linking of IgE

Question 23

What type of hypersensitiviet reaction are mast cells associated with?

Answer 23

Type I

Question 24

What asthma treatment prevents the degranulation of mast cells?

Answer 24

Cromolyn sodium

Question 25

"highly phagocytic APCs that functions as a link between innate and adaptive immune systems"

Answer 25

dendritic cells

Question 26

Which lymphocyte is part of the innate immune system?

Answer 26

Natural killer cells

Question 27

Name the cell type: | CD19 + CD20 + CD21

Answer 27

B cell

Question 28

Name the cell type: | CD19 + CD20 + CD21

Answer 28

B cell

Question 29

What part of the spleen can B cells mature?

Answer 29

While pulp

Question 30

Name the Cell type: | CD3 + CD4/8

Answer 30

T cell

Question 31

What is the costimulatory signal needed for T cell activation?

Answer 31

CD28

Question 32

ABO antibodies are Ig?

Answer 32

IgM

Question 33

Rh antibodies are Ig?

Answer 33

IgG

Question 34

What can cause hemolytic disease of the newborn?

Answer 34

Anti-D- IgG from the mom cross the placenta and canse erythroblastosis fetalis int he next Rh+ fetus

Question 35

What does VIIIa activate?

Answer 35

IXa so that it can cleave X

Question 36

What cleaves VIII?

Answer 36

IIa (thrombin)

Question 37

What cleaves V?

Answer 37

IIa (thrombin)

Question 38

Which anticoagulant has the greatest effect on IIa (heparin)?

Answer 38

Heparin

Question 39

What anticoagulant has the highest effect on Xa?

Answer 39

LMWH

Question 40

What factor activates II?

Answer 40

Va and Xa

Question 41

"deficiency of factor VIII (XR)"

Answer 41

Hemophelia A

Question 42

"deficiency of factor IX (XR)"

Answer 42

Hemophelia B

Question 43

"deficiency of factor XI (XR)"

Answer 43

Hemophelia C

Question 44

What factors cleavages require Ca2+?

Answer 44

VII, XIIa, IXa/ VIIIa, Xa/ Va 5, 7-10

Question 45

What enzyme is inhibited by warfarin?

Answer 45

vitamin K epoxide reductase

Question 46

What factors does warfarin interfere with?

Answer 46

I, VII, IX, X, protein C and protein S

Question 47

What enzyme activates plasminogen?

Answer 47

tPA

Question 48

Heparin enhances the activity of ________

Answer 48

antthrombin (which targets Xa and IIa)

Question 49

What is the mutation seen in factor V leiden mutation?

Answer 49

produces a factor V resistant to inhibition by activated protein C

Question 50

What releases vWF?

Answer 50

Weibel- Palade Bodies and alpha granules of platelets

Question 51

Once platelets bind vWF via GpIb what do they release?

Answer 51

ADP, Ca2+ and TXA2

Question 52

What incudes the expression of GpIIb/ IIIa on platelets?

Answer 52

ADP binding platelets