Resp Pharm High Yield Flashcards
Name the class:
Loratadine
Fexofenadine
Desloratidine
Cetirizine
2nd generation H1 blocker
Name the class:
Diphenhydramine
Dimenhydrinate
Chlorphehydramine
1st generation H1 blockers
What are the H1 blockers used for?
Allergies
What is Gauifenesin?
Expectorant–> thins respiratory secretions
What is NAC?
Mucolytic (loosens mucus plugs in a paint with CF bu disrupting disulfide bonds)
What is dextromethorphan?
Antitussive (antagonizes NMDA glutamate receptors–> codeine analog)
What is the mechanism of pseudoephedrine and phenylephrine?
Alpha adrenergic agonists (as a nasal degongestant)
What is bosentan?
Endothelin receptor antagonist used to treat pulmonary HTN
What is the AE of bosentan?
Hepatotoxic
What are PDE-5 inhibitors used to treat?
ED
Pulm HTN
What 2 factors cause bronchosconstriction in asthma?
1- inflammatory process
2- Parasympathetic tone
Which beta 2 agonist is used for acute attacks?
albuterol
Which beta 2 antagonist is used for prophylaxis?
Salmeterol/ formoterol
What is 1st line therapy for chronic asthma?
Corticosteroids
What is the mechanism of ipratropium?
M blocker–> prevent bronchoconstriction
What is ipratropium used to treat?
COPD and asthma
Which drug is an inhibitor of 5- lipoygenase pathway?
Zileutron
What drugs block leukotriene receptors?
Montelukast
Zafirlukast
What is omalizumab?
monoclonal anti-IgE antibody
What is the mechanism of theophylline?
Causes bronchodilation by inhibiting phosphodiesterase leading to increased cAMP
What are the AE of theophylline?
Cardiotoxicity, neurotoxicity
What is used in aspirin induced asthma?
Montelukast, zafirlukast
What is used in allergic asthma resistant to inhaled steroids and long acting Beta 2 agonists?
Omalizumab
