Jaundice Flashcards
What is the breakdown product of haemoglobin?
Bilirubin
What is unconjugated bilirubin?
Initial breakdown product which circulates into the blood and is then take up by liver
What conjugates unconjugated bilirubin?
The liver metabolises and conjugates the bilirubin
Associated symptoms of jaundice?
Itch Joint pain Abdominal pain Abdominal bloating Bruising/bleeding Dark urine Light or dark stool Tiredness, wt loss, malaise, fever, SOB
Social indications of jaundice?
IVDU Tattoos Piercings Travel Sexual activity Alcohol/drugs
General investigations?
FBC LFT Liver screen U& E Amylase Urine Imaging: abdo US
Prehepatic jaundice LFTs, stool & urine?
Normal LFTs
Raised unconjugated bilirubin
Normal stool
Normal urine
Diseases for pre-hepatic jaundice?
Malaria
Haemolytic anaemia
Diseases for intra-hepatic jaundice?
Viral Alcohol Drugs Ischemia Gilberts syndrome
LFT, Stool and urine for intra-hepatic jaundice?
Raised AST/ALT
Raised conjugated/unconjugated bilirubin
Normal stool
Dark, raised urobilinogen in urine
Post-hepatic jaundice diseases?
Gallstones
PSC/PBC
Cholangiocarcinoma
Pancreatic cancer
LFTs, Urine and stool for post-hepatic jaundice?
Raised ALP/GGT
Raised conjugated bilirubin
Pale stool
Dark Urine, reduced urobilinogen
What is Gilberts syndrome?
Congenital unconjugated hyper-bilirubinemia
Jaundice develops asymptomatically
Self-limiting, no active treatment
