Chronic Liver Disease yeet

Question 1

What is chronic liver disease?

Answer 1

• Liver disease with duration more than 6 months
• Can lead to development of cirrhosis
• Recurrent inflammation of liver and repair with fibrosis and regeneration over time it will progress to cirrhosis
• Once decompensated cirrhosis occurs there will be liver failure

Question 2

Causes of chronic liver disease?

Answer 2

Alcohol 
NAFLD
Hep C 
Primary biliary cholangitis 
AI hepatitis 
Hep B 
Haemochromatosis 
PSC (primary sclerosing cholangtis)
Wilson's disease 
ALpha 1 anti-trypsin 
Buddi-Chiari
Methotrexate

Question 3

What is Wilson’s disease + treatment?

Answer 3

Genetic condition

Treat with copper chelation drugs

Question 4

What is alpha-1-antitrypsin?

Answer 4

Genetic condition

Causing lung emphysema & liver damage

Question 5

What is buddi chiari?

Answer 5

Thrombosis of the hepatic veins treated with recanalization or TIPs after US diagnosis

Question 6

Signs of chronic liver disease?

Answer 6

Stigmata: spiders, fetor, encephalopathy
Synthetic dysfunction
Prolonged prothrombin time, hypoalbuniaemia