tumor suppressor genes

Question 1

Rb

Answer 1

retinoblastoma

osteosarcoma

Question 2

bilateral (25% cases, all caused by inherited point mutations)
unilateral (75% cases, sporadic or inherited mutation)
mutations in BOTH alleles → cancer (2 hits = TWOmur suppressor)
inherited: 1 hit from parent gene, other sporadic: both sporadic
sp

Answer 2

retinoblastoma

Question 3

tumor outgrows vascularity in retina

no red reflex (white reflex)

Answer 3

retinoblastoma

Question 4

p53

Answer 4

more than 50% human cancers

Question 5

APC

Answer 5

familial adenomatous polyposis → colon cancer

Question 6

BRCA

Answer 6

breast cancer (3% cases) + ovarian cancer
BReast CAncer

Question 7

DPC (SMAD4)

Answer 7

Deleted in Pancreatic Cancer

Question 8

DCC

Answer 8

Deleted in Colon Cancer

Question 9

NF1

Answer 9

neurofibromatosis type 1 (fleshy nuerofibromas in skin)

on chrom 17 (17 words in neurofibromatosis)

Question 10

NF2

Answer 10

neurofibromatosis type 2: bilateral acoustic schwannoma (neuroma)
on chrom 22 (NF 2)

Question 11

WT1 and WT2

Answer 11

wilms tumor

Question 12

VHL

Answer 12

von hippel-lindau

Question 13

TSC

Answer 13

tuberous sclerosis