immune system basics

Question 1

under-developed paracortex of lymph node

no mature T cells → no thymus for T cell maturation

Answer 1

DiGeorge syndrome

Question 2

follicle of cortex of lymph node

Answer 2

B cells

Question 3

paracortex of lymph node

Answer 3

T cells

Question 4

medullary cords of lymph node

Answer 4

plasma cells

Question 5

medullary sinus of lymph nodes

Answer 5

macrophages

Question 6

peyer’s patches are located in

Answer 6

lamina propria + submucosa of ileum only

Question 7

DC found in epidermal layers of skin

Answer 7

langerhan cells (cutaneous associated lymphoid tissue)

Question 8

DC found in interstitial spaces of all organs (except brain)

Answer 8

interstitial dendritic cells

Question 9

excessive proliferation of Langerhan cells in epidermis

not able to act as APC to T helper cells

Answer 9

langerhans cell histiocytosis

Question 10

+ S-100 tumor marker

CD1a surface marker

Answer 10

langerhan cell histiocytosis

Question 11

Birbeck granules “tennis rackets” on EM

Answer 11

langerhan cell histiocytosis

Question 12

mu heavy chain isotype

Answer 12

IgM

Question 13

delta heavy chain isotype

Answer 13

IgD

Question 14

gamma heavy chain isotype

Answer 14

IgG

Question 15

alpha heavy chain isotype

Answer 15

IgA

Question 16

epsilon heavy chain isotype

Answer 16

IgE

Question 17

uncontrolled proliferation of 1 plasma cell producing 1 type of antibody causes

Answer 17

multiple myeloma

Question 18

scewed kappa:lambda light chain ratio suggests

Answer 18

multiple myeloma

Question 19

normal kappa:lambda light chain ratio

Answer 19

2 kappa: 1 lambda

Question 20

function of macrophages in spleen

Answer 20

remove abnormal RBCs (spherocytes in hereditary spherocytosis)
remove encapsulated bacteria