oncogenes Flashcards
1
Q
K-RAS mutation
A
colon cancer (Kolon) lung cancer pancreatic cancer (panKreatic)
2
Q
H-RAS mutation
A
bladder + kidney tumors (Hematuria)
3
Q
N-RAS mutation
A
melanoma
hematologic malignancy
follicular thyroid cancer
4
Q
BCR-ABL:
ABL codes for non-receptor tyrosine kinase
ABL gene translocated from 9 to BCR gene on 22 t(9;22) = philadelphia chromosome
always ON
A
CML
5
Q
RET:
receptor tyrosine kinase always activated (don’t need GF to bind to R outside cell anymore)
A
1) MEN 2A and 2B:
pheochromocytoma
medullary thyroid cancer
2) papillary carcinoma of thyroid
normal RET protein is expressed in neuroendocrine cells: adrenal medulla, parafollicular C cells of thyroid
6
Q
HER2/neuL receptor tyrosine kinase
A
breast cancer
ovarian cancer
gastric cancer
7
Q
C-myc
A
burkitt lymphoma
8
Q
L-myc
A
lung tumors
9
Q
M-myc
A
neuroblastoma: mostly in adrenal medulla
