category X teratogen Flashcards
1
Q
Methotrexate: inhibit folate metabolism
A
neural tube defects
use: cancer drug, inflammatory disease (SLE, psoriasis, RA), ectopic pregnancy
2
Q
Statin: inhibit cholesterol synthesis (steroid hormones)
A
CNS + limb
3
Q
Warfarin: anticoagulant
USE HEPARIN - DOESN’T CROSS PLACENTA
A
facial + limb + CNS
spontaneous abortion
4
Q
Isotretinoin: Vit A derivative
A
skull + CNS + heart + parathyroid + cleft palate
interfere with homeobox/HOX gene expression
spontaneous abortion
5
Q
DES (diethylstilbestrol)
A
clear cell vaginal adenocarcinoma in teen/20s
6
Q
Thalidomide: sedative, leprosy, multiple myeloma (elderly dz)
A
phocomelia (LIMB hypoplasia = tha-LIMB-domide)
7
Q
category X teratogens
A
MTX warfarin statin isotretinoin DES thalidomide
