macrophages + granulocytes + cytokines Flashcards
conditions that result in splenectomy
sickle cell patient: autoinfarction of spleen overtime
trauma: MVA
hereditary spherocytosis: defective RBCs removed by macrophages in spleen, remove spleen to allow defective RBCs to still circulate
complication of splenomegaly
allows for more sequestration + storage of
platelets → thrombocytopenia
monocyte differentiation in skin + CT
dendritic cells (histiocytes): type of APC: engulf antigen in periphery → migrate to LYMPH NODE to present to T cell for T cell activation + differentiation *dendritic cells found throughout body but first identified in skin
monocyte differentiation in alveoli + intestines + spleen
macrophages
type of APC: engulf antigen → STAY in location to fight (don’t go to lymph node)
monocyte differentiation in liver
Kupffer cells
monocyte differentiation in brain
microglia
monocyte differentiation in bone
osteoclasts
monocyte differentiation in joints
type A synoviocytes: clean synovial fluid
make hyaluronic acid (component of synovial fluid) in joints
type B synoviocytes
neutrophil chemotactic agents
IL-8
C5a
leukotriene B4
Kallikrein
T cell proliferation, differentiation, activation
IL-2
supports growth + differentiation of bone marrow stem cells
IL-3
released by virus-infected cells
IFN alpha + beta
inhibits production of Th2
IFN gamma
inhibits production of Th1
IL-10
secreted by Th2, inhibits macrophage activation
IL-10
secreted by Th1, activates macrophages
IFN gamma
mediate inflammation
IL-1
IL-6
TNFalpha
enhance synthesis of IgA
IL-5
enhance synthesis of IgE and IgG
IL-4 (BEG 4 it)
pyogens secreted by macrophages
IL-1
IL-6
promotes growth + activation of eosinophils
IL-5
promotes growth + differentiation of B cells
IL-4
IL-5
produced by Th2 cells
IL-2 IL-3 IL-4 IL-5 IL-10
produced by Th1 cells
IL-2
IL-3
IFN gamma
enzyme that activates transcription of IL-2 (for T cell differentiation, activation)
calcineurin: protein phosphatase
regulatory enzyme involved in IL-2 driven T cell proliferation
mTOR
immunoglobulin isotype associated with eosinophilia?
cytokine associated with differentiation of eosinophils?
IgE associated with eosinophilia
IL-5 associated with differentiation of eosinophils
