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DIT topics > macrophages + granulocytes + cytokines > Flashcards

macrophages + granulocytes + cytokines Flashcards

1
Q

conditions that result in splenectomy

A

sickle cell patient: autoinfarction of spleen overtime
trauma: MVA
hereditary spherocytosis: defective RBCs removed by macrophages in spleen, remove spleen to allow defective RBCs to still circulate

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2
Q

complication of splenomegaly

A

allows for more sequestration + storage of

platelets → thrombocytopenia

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3
Q

monocyte differentiation in skin + CT

A 
dendritic cells (histiocytes): type of APC: engulf antigen in periphery → migrate to LYMPH NODE to present to T cell for T cell activation + differentiation
*dendritic cells found throughout body but first identified in skin
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4
Q

monocyte differentiation in alveoli + intestines + spleen

A

macrophages

type of APC: engulf antigen → STAY in location to fight (don’t go to lymph node)

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5
Q

monocyte differentiation in liver

A

Kupffer cells

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6
Q

monocyte differentiation in brain

A

microglia

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7
Q

monocyte differentiation in bone

A

osteoclasts

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8
Q

monocyte differentiation in joints

A

type A synoviocytes: clean synovial fluid

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9
Q

make hyaluronic acid (component of synovial fluid) in joints

A

type B synoviocytes

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10
Q

neutrophil chemotactic agents

A

IL-8
C5a
leukotriene B4
Kallikrein

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11
Q

T cell proliferation, differentiation, activation

A

IL-2

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12
Q

supports growth + differentiation of bone marrow stem cells

A

IL-3

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13
Q

released by virus-infected cells

A

IFN alpha + beta

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14
Q

inhibits production of Th2

A

IFN gamma

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15
Q

inhibits production of Th1

A

IL-10

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16
Q

secreted by Th2, inhibits macrophage activation

A

IL-10

17
Q

secreted by Th1, activates macrophages

A

IFN gamma

18
Q

mediate inflammation

A

IL-1
IL-6
TNFalpha

19
Q

enhance synthesis of IgA

A

IL-5

20
Q

enhance synthesis of IgE and IgG

A

IL-4 (BEG 4 it)

21
Q

pyogens secreted by macrophages

A

IL-1

IL-6

22
Q

promotes growth + activation of eosinophils

A

IL-5

23
Q

promotes growth + differentiation of B cells

A

IL-4

IL-5

24
Q

produced by Th2 cells

A 
IL-2
IL-3 
IL-4
IL-5
IL-10
25
Q

produced by Th1 cells

A

IL-2
IL-3
IFN gamma

26
Q

enzyme that activates transcription of IL-2 (for T cell differentiation, activation)

A

calcineurin: protein phosphatase

27
Q

regulatory enzyme involved in IL-2 driven T cell proliferation

A

mTOR

28
Q

immunoglobulin isotype associated with eosinophilia?

cytokine associated with differentiation of eosinophils?

A

IgE associated with eosinophilia

IL-5 associated with differentiation of eosinophils

DIT topics (115 decks)

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