renal embryology + basics

Question 1

kidney embryology

Answer 1

pronephros: present at wk 4 → disappears
mesonephros: fetal kidney during 1st tri, becomes male genital system
metanephros: present at wk 5 → adult kidney

Question 2

caudal mesonephros (closest to feet) develops a

Answer 2

mesonepheric → ureteric bud: becomes collecting duct, renal calyces, ureter
ureteric bud induces metanephros: becomes renal tubular epithelial structures (nephron)
like mesodermal notochord inducing ectoderm above to form neural tube

Question 3

ureteric bud (collecting duct, calyces, ureter) fail to develop from caudal mesonephros

Answer 3

Potter sequence due to bilateral renal agenesis (no kidneys!):
no collecting system (no ureteric bud from caudal mesonephros)
no nephrons (no metanephros induction)

Question 4

deficient transporter for neutral amino acids (tryptophan) in PCT → can't make niacin (vit B3)→ 3 D's of pollagra:
dermatitis
diarrhea
dementia
death

Answer 4

hartnup disease