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► Med - Pathology > Pathology of the Male GU II: Penis and Testes > Flashcards

Pathology of the Male GU II: Penis and Testes Flashcards

1
Q

Hypospadias

A

Urethral opening on the ventral surface

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2
Q

Epispadias

A

Urethral opening on the dorsal surface

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3
Q

Phimosis

A

Prepuce cannot be retracted

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4
Q

Paraphimosis

A

Phimotic prepuce is forcibly retracted leading to pain and urinary retention

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5
Q

Reiter Syndrome

A

Combination of conjunctivitis, polyarthritis and genital infection often caused by Chlamydia trachomatis

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6
Q

Which HSV causes gingivostomatitis?

A

HSV-1

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7
Q

Which HSV causes genital herpes?

A

HSV-2

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8
Q

What are the histological signs of herpes infection?

A

Multinucleation - Margination - Molding

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9
Q

Condyloma Acuminatum

A

Genital wart caused by HPV-6 and 11

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10
Q

What are risk factors for SCC of the penis?

A

Poor hygiene and phimosis - accumulation of smegma, and history of genital warts.

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11
Q

Cryptorchidism

A

Undescended testis

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12
Q

What chromosome abnormality is cryptorchidism associated with?

A

Trisomy 13

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13
Q

Reiter Syndrome

A

Combination of conjunctivitis, polyarthritis and genital infection often caused by Chlamydia trachomatis

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14
Q

Seminoma

A

Localized to testis for long time and have little metastasis - very radiosensitive and have a good prognosis

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15
Q

What are risk factors for SCC of the penis?

A

Poor hygiene and phimosis - accumulation of smegma, and history of genital warts.

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16
Q

What will be seen on histology with cryptorchidism?

A

Testicular atrophy

17
Q

Varicocele

A

Dilated veins in the spermatic cord with a “bag of worms” feeling

18
Q

Testicular Torsion

A

Twisting of the cord with thick-walled arteries patent but the veins are blocked off leading to vascular engorgement and eventual infarction

19
Q

What race are testicular tumors more common in?

A

Caucasians

20
Q

Nonseminomatous GCTs

A

More aggressive than seminomas with hematogenous spread and are radio resistant but most can be cured with aggressive chemotherapy.

21
Q

What is the risk for testicular cancer with cryptorchidism?

A

The higher the testis location, higher the risk of cancer - risk is greater in the right than the left

22
Q

Is trauma a risk factor for testicular cancer?

A

NO

23
Q

What is a chromosome found with invasive testicular tumors?

A

12i Chromosome

24
Q
  • Seen often associated with malignant germ cell tumors
  • Intratubular proliferation of malignant germ cells
  • Large atypical cells, abundant clear cytoplasm, central nucleus, prominent nucleoli “fried egg”
A

Intratubular Germ Cell Neoplasia

25
Q

What is the most common germ cell tumor in males?

A

Seminoma

26
Q

What can rarely be increased as a marker in seminomas?

A

beta-HCG

27
Q

Embryonal Carcinoma

A

Large anaplastic cells with prominent nucleoli with indistinct cell borders arranged in solid, glandular, tubular, papillary patterns.

28
Q

Yolk Sac Tumor

A

Most common testicular tumor in infants up to 3 yrs - reticular network of cuboidal cells, papillary and solid patterns (Schiller-Duval or glomeruloid bodies) and hyaline-like globules

29
Q

Choriocarcinoma

A

Highly aggressive and invasive into the blood with beta-HCG as a marker

30
Q

Teratoma

A

Always malignant in males - Random admixture of tissue derived from ectoderm, endoderm and mesoderm

31
Q

Leydig Cell Tumor

A
  • Most common sex-cord stroll tumor in males
  • Usually unilateral
  • Well circumscribed
  • Crystalloids of Reinke
32
Q

Lymphoma of the Testicle

A

Usually secondary. The most common - large B-cell lymphoma and is most commonly seen in patients greater than 60 yrs

33
Q

Most common testicular tumor in adults?

A

Seminoma

34
Q

Most common bilateral primary testicular tumor?

A

Seminoma

35
Q

Most common bilateral testicular tumor?

A

Lymphoma

36
Q

Most common testicular cancer in infants and children?

A

Yolk Sac Tumor

37
Q

Most common nongerm cell tumor of the testis?

A

Leydig Cell Tumor

38
Q

Which are more common in the testis - mixed tumors or pure histologic types of tumors?

A

Mixed

► Med - Pathology (203 decks)

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