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► Med - Pathology > Herpes I > Flashcards

Herpes I Flashcards

1
Q

What kind of genetic material is in herpes viruses?

A

DNA

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2
Q

Are herpes viruses enveloped?

A

Yes

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3
Q

What is the acute infection caused by HSV Type I?

A

Cold Sores

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4
Q

What is the acute infection caused by HSV Type II?

A

Genital Herpes

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5
Q

What is the acute infection caused by Varicella-Zoster Virus (VZV)?

A

Chicken Pox

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6
Q

What is the acute infection caused by EBV?

A

Infectious Mononucleosis

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7
Q

What is the acute infection caused by HSV 6?

A

Roseola

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8
Q

What is the acute infection caused by HSV 7?

A

Roseola

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9
Q

What does the reactivation of VZV cause?

A

Shingles

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10
Q

Where does HSV Type I viral DNA reside latently?

A

Sensory cells of the trigeminal nerve ganglion

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11
Q

Where does viral DNA of HSV Type II reside?

A

Viral DNA resides in sensory cells of sacral ganglion

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12
Q

What drugs are used to treat HSV Type I and II?

A

Acyclovir and Priteliver

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13
Q

Acyclovir MOA

A

Aciclovir is converted by viral thymidine kinase to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP). ACV-TP, in turn, competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes

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14
Q

What viral enzyme is required for the function of acyclovir?

A

Viral thymidine kinase

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15
Q

Pritelivir MOA

A

Directed against herpesvirus helicase-primase inhibiting the formation of helices-primase and DNA replication

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16
Q

What is the initial VZV infection known as?

A

Varicella

17
Q

What is the reactivation of VZV infection known as?

A

Zoster

18
Q

What are some complications of varicella?

A
  • Bacterial infection
  • CNS manifestations
  • Pneumonia (rare)
19
Q

Wha type of vaccine is Varivax?

A

Live-attenuated virus

20
Q

Where does latent VZV reside?

A

Doral root ganglion

21
Q

What can reduce incidence of herpes zoster in the elderly?

A

Immunization or re-vaccination with VZV

► Med - Pathology (203 decks)

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