Oncogenic Viruses

Question 1

What viruses are indirectly linked to HCC?

Answer 1

HBV and HBC

Question 2

What virus is linked with Kaposi sarcoma?

Answer 2

HHV-8

Question 3

What virus is linked with cervical carcinoma?

Answer 3

HPV

Question 4

What is the most common viral associated cancer in males?

Answer 4

Liver Cancer

Question 5

What is the most common viral associated cancer in females?

Answer 5

Cervical Cancer

Question 6

What are the high risk HPV types?

Answer 6

16, 18, 31 and 33

Question 7

What are the low risk HPV types?

Answer 7

6 and 11

Question 8

What are the E genes of HPV used for?

Answer 8

The E “early” genes are transcribed shortly after basal keratinocytes are infected - E6 and E7 are the most important as inactivators

Question 9

What phase do Rb and p53 act at?

Answer 9

G1-S Checkpoint

Question 10

Why are HPVs 16, 18, 31 and 33 “high – risk”, while other HPVs are “low‐risk” for cancer?

Answer 10

They make E6 and E7 to inhibit tumor suppressor proteins

Question 11

When will the HPV vaccine be ineffective?

Answer 11

Ineffective if patient already has CIN

Question 12

Imiquimod MOA

Answer 12

Synthetic TLR7 agonist that induces proinflammatory cytokines, notably interferons, which attract antiviral effector cells to destroy warts

Question 13

Cidofovir MOA

Answer 13

Cidofovir is a nucleoside analog that blocks DNA polymerases; standard use is to reduce herpes infections but topical cidofovir has been shown to reduce some HPV‐induced warts