Clinical ID Flashcards
Prions
Composed of modified proteins that cause transmissable disesases
Viruses
Obligate intracellular organisms that are dependent on host cell metabolism for replication
What type of pathogen is capable of long term latency in the host?
Viruses
Bacteriophages/Plasmids/Transposons
Mobile genetic elements that encode bacterial virulence factors.
Bacteriophages only infect bacteria.
Chlamydiae
Can cause GU infections, conjunctivitis, respiratory infections & STDs
Rickettsiae
Transmitted by insect vectors (lice, ticks, mites) and can cause Rocky Mountain Spotted Fever, Q Fever, ehrlichiosis & scrub typhus
Mycoplasmas
Tiniest free-living organism known and can cause atypical pneumonia & nongonococcal urethritis
What are the conidia of the fungi?
Fruiting bodies off of the hyphae
Protozoa
Parasitic, single-celled organisms with motility, pliable plasma membranes and complex cytoplasmic organelles
Helminths
Parasitic worms that are highly differentiated multicellular organisms
What are the 3 types of helminths?
- Roundworms
- Flatworms
- Flukes
Example of roundworm
Nematode
Example of a flatworm
Tapeworm
Example of a fluke
Trematodes
What are the main barriers to infection?
Skin and mucosa along with secretions such as lysozyme and stomach acid.
What are the mechanisms of bacteria induced cell injury?
- Cell Death
- Toxins
- Secondary injury due to the immune response
What is bacterial endotoxin?
Toxin that is a part of the LPS in Gram (-) bacteria and is on Lipid A
What is bacterial exotoxin?
Toxins that are released by the bacteria to interfere with cellular metabolism to kill surrounding cells and increase the nutrients available to them
What are examples of microbial pathogens that exhibit significant antigenic variation?
Rhinovirus Influenza Giardia Lamblia N. gonorrhoea Plasmodium falciparum
Giardia lamblia would most appropriately be classified as:
- Bacteria
- Fungus
- Protozoa
- Helminth
- Virus
- Protozoa
Which of the following are considered to be part of the human host barriers to infection?
- Intact skin
- Lysozme in tears
- Acid in stomach
- Commensal flora of mucous membranes
- All of the above
- All of the above
The lipopolysaccharide (LPS): structural component of outer cell wall in gram negative bacteria that induces host cytokine release to cause fever, activate macrophages & B cells is know as:
- Exotoxin
- Endotoxin
- Lipoteichoic acids
- Integrins
- Peptidoglycan
- Endotoxin
Which of the following microbial pathogens exhibits significant antigenic variation?
- Bacillus anthracis
- Neisseria gonorrhoeae
- Shigella dysenteriae
- Streptococcus pyogenes (GroupAStrep)
- Vibrio cholera
- Neisseria gonorrhoeae
Suppurative (Polymorphonuclear) Inflammation
- Caused by pyogenic bacteria
- Characterized by increased vascular permeability and leukocytic infiltration by neutrophils
What can cause suppurative inflammation?
Pneumococcal pneumonia
Mononuclear and Granulomatous Inflammation
Diffuse, predominantly mononuclear interstitial infiltrates form in response to pathogens
What can cause granulomatous inflammation?
Syphilis
Tuberculosis
Cytopathic-Cytoproliferative Inflammation
Reactions characteristic of virus-mediated damage to individual host cells in the absence of host inflammatory responses
What can cause cytopathic-cytoproliferative inflammation?
Herpes
Measles
Necrotizing Inflammation
Rapid and severe tissue damage with predominant cell death in the absence of inflammatory infiltrates
What can cause necrotizing inflammation?
Caused by uncontrolled viral infections, secreted bacterial toxins or cytolysis of host cells in protozoa infections (eg. Necrotizing fasciitis caused by Group A streptococcus)
Chronic Inflammation and Scarring
Chronic inflammation can lead to either complete healing or to extensive scarring due to constant damage from inflammation
What can cause chronic inflammation?
Schistosoma haematobium - shistosoma eggs
Poliovirus
Virus
Staphylococcus epidermis
Bacteria
Candida albicans
Fungi
Sporothrix shenckii
Fungi
Histoplasma capsulatum
Fungi
Giardia lamblia
Protozoa
Trypanosoma gambiense
Protozoa
Enterobius vermicularis
Helminthes
Trichinella spiralis
Helminthes