Intracellular compartment & protein transport Flashcards
__________ cells contain a basic set of membrane - enclosed organelles
Eukaryotic
The ________ is the most prominent organelle in cells & is surrounded by the nuclear envelope & communitcates through its nuclear pore
Nucleus
The ____________ is the main place where new membranes are formed in the cell
Endoplasmic Retriculum (ER)
The ___________ receives proteins & lipids from the ER & modifies them & transfer thme to the desire place
Gogi Apparatus
__________ & the __________ are both the place where oxidative phosphorylation & photosynthesis occur & produce ATP
Mitochondria & the chloroplast
Endomembrane system
Consist of the ER, gogi apparatus, peroxisomes, endosomes, & lysosomes
What are the three ways proteins are transported into organelles?
- Proteins moving from the cytosol to the nucleus are transfered through the nuclear pores
- Proteins moving from the cytosol to the ER, mitchondria, or chlorplast are transported by protein translocators
- Proteins moving from the ER or from one part of the endomembrane system to another are transported by transport vesicles
The organelle that a protein is delivered to depends on its ___________ (which contains sorting signals to tell where the protein needs to be)
Amino Acid Sequence
Peroxisomes
Are small organelles that contain enzymes that break down lipids & destroy toxic molecules which produces H2O2
__________ direct proteins to the correct organelle
Singal Sequences
Nuclear Envelope
Encloses the nucleus & defines the nucleus
Nuclear Pores
Form gates within the nucleus envelope and allow molecules in or out the nucleus
Nuclear localization signal
The singal sequence that directs a proteins from the cytosol into the nucleus
Nuclear import receptors
Recognize the nuclear localization singal & helps direct the protein to a nuclear pore & into the nucleus
Proteins ________ to enter the mitochondria & chloroplast
Unfold
____________ proteins help pull the proteins through the outer & inner membranes of the mitochondria or chloroplast & fold the proteins back up once inside
Chaperone
Proteins enter peroxisomes from both the ___________ & the _________
Cytosol & the ER
Peroxisomes are packed with ___________ that digest toxins & synthsize certain phospholipids
Enzymes
What are the two types of proteins that are transferred from the cystosol to the ER?
- Water soluble proteins
- Prospective transmembrane proteins
What are the two types of proteins that help guide the ER sginal sequences to the ER membrane?
- Signal -recognition particle (SRP)
- An SRP receptor
Signal recognition particle (SRP)
Binds both the ribosome & the ER signal sequence
An SRP Receptor
Recognizes the SRP
________ & _______ signals determine the arrangment of a transmembrane proteins in the lipid bilayer
Start & Stop
___________ carry soluble proteins& membrane between organelles
Transport Vesicles
___________ allows materials to exit / enter the cell by endocytosis or exocytosis
Vesicular Transport
Vesicles budding is driven by the assembly of a ____________
Protein Coat
Coated vesicles
Vesicles that have a protein coat
Rab Proteins
Proteins on the vesicles that get recognized for the vesicle to fuse
Tethering proteins
Recognize the rab proteins
SNAREs (v- SNAREs)
Firmly docks the vesicles in place & catalyze the membrane fusion
Unfolded proteins response (UPR)
Allows the cell to adjust the size of the ER to properly handle the volume of proteins entering
___________ are released from the cell by exocytosis
Secretory Proteins
Secretory Vesicles
Comes from the gogi appartus & are destined near the plasma membrane & relase their contents into the exterior of the cell
What are the two types of endocytosis?
- Pinocytosis
- Phagocytosis
Pinocytosis
Involves the ingestion of fluid & molecules
Phagocytosis
Involves the ingestion of large particles
Phagocytosis cells
Defend us against inflection by ingesting invading microorganisms
Fluid & macromolecules are taken up by ___________
Pinocytosis
__________ are the main place where intracellular digestion occurs
Lysosomes