3.14 Ch. 12.2 Flashcards

1
Q

types of peripheral neuropathies

A
  • mononeuropathy
  • multiple mononeuropathy
  • polyneuropathy
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2
Q

mononeuropathy

A

Involves a single nerve and is considered a focal dysfunction

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3
Q

multiple mononeuropathy

A
  • Involves several nerves

- is multifocal (i.e., asymmetrically involves individual nerves).

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4
Q

polyneuropathy

A
  • Involves many nerves

- is a generalized disorder that typically has a distal and symmetrical presentation.

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5
Q

3 categories of traumatic injuries

A
  • traumatic myelinopathy
  • traumatic axonopathy
  • severance
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6
Q

traumatic myelinopathy refers to the loss of

A
  • myelin

- limited to the site of injury

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7
Q

peripheral myelinopathies interfere with

A

function of large-diameter axons

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8
Q

What causes traumatic myelinopathy?

A

focal compression of a peripheral nerve

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9
Q

What can cause focal compression?

A

repeated mechanical stimuli

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10
Q

Where does traumatic axonopathy occur?

A

distal to the lesion

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11
Q

What does traumatic axonopathy disrupt?

A
  • axons

- Wallerian degeneration

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12
Q

What does traumatic axonopathy affect?

A
  • all sizes of axons
  • reflexes
  • somatosensation
  • motor functions

**reduced or absent

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13
Q

traumatic axonopathy and regenerating axons

A

Regenerating axons are able to reinnervate appropriate targets because myelin and connective tissues remain intact.

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14
Q

When does severance occur?

A
  • when nerves are physically divided by excessive stretching or laceration
  • axons and connective tissue are completely interrupted
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15
Q

What does severance result in immediately?

A
  • loss of sensation

- muscle paralysis in area supplied

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16
Q

What happens if proximal and distal nerve stumps are apposed and scarring does not interfere?

A

some sprouts enter the distal stump and are guided to their target tissue in the periphery

17
Q

What does multiple mononeuropathy involve?

A

two or more nerves in different parts of the body

18
Q

What may cause multiple mononeuropathy?

A

vasculitis

19
Q

What should be done if vasculitis is suspected?

A

an urgent referral should be made for an electrodiagnostic evaluation

20
Q

nerves affected with multiple mononeuropathy

What does this produce?

A
  • individual nerves are affected

- produces a random, asymmetrical presentation of signs

21
Q

hallmark signs of polyneuropathy

A
  • symmetrical involvement of sensory, motor, and autonomic fibers
  • often progresses from distal to proximal
22
Q

Polyneuropathies are NOT the result of

A
  • trauma

- ischemia

23
Q

causes of polyneuropathies (Categories)

A
  • toxic
  • metabolic
  • autoimmune
24
Q

Most common causes of polyneuropathies

A
  • diabetes
  • nutritional deficiencies 2˚ to alcoholism
  • autoimmune diseases

(also some therapeutic drugs, industrial and agricultural toxins, and nutritional disorders)

25
Q

polyneuropathy in Guillain-Barré has more severe effects on (motor/sensory) than (motor/sensory) system

A

motor

sensory

26
Q

Guillain-Barré: proximal

A

paresis may be worse

27
Q

Guillain-Barré: onset

A
  • rapid with progressive paralysis

- urgent dx and tx required to prevent respiratory failure

28
Q

Guillain-Barré: patients requiring a ventilator

A

1/3 of pts will need a ventilator

29
Q

most common inherited form of polyneuropathy

A

Charcot-Marie-Tooth disease

30
Q

Charcot-Marie-Tooth disease: onset

A

typically occurs in adolescence or in young adults but varies with type

31
Q

Charcot-Marie-Tooth disease: presentation

A

paresis of muscles distal to knee with

  • foot drop
  • steppage gait
  • frequent tripping
  • muscle atrophy

in progression, atrophy and paresis affect hands