1.20 Week 2:1 Flashcards
treatment of lead poisoning
chelation therapy
Why is lead poisoning so bad?
It’s a competitive inhibitor that mimics calcium, magnesium, etc. (2+)
lead poisoning neurological damage
irreversible
pro/con to chelation therapy
- can remove lead from the body
- not successful in children
What can Zika virus cause?
microcephaly
Zika virus: infection
- mosquito borne
- affects current pregnancy (not future ones)
- recently occurring a lot in Brazil
Zika virus: infection early in pregnancy
affects neural tube closing (and subsequent microcephaly)
Zika virus: infection later in pregnancy
Guillon-Barré
What if a child with microcephaly survive? What will they need?
likely need lifelong PT, OT, etc
demyelination: Which cells are affected in the CNS?
oligodendrocytes
demyelination: Which cells are affected in the PNS?
Schwann cell
early stage demyelination in CNS/PNS
appear similar in early stages
demyelination of the CNS: regeneration
doesn’t have much if any regenerative capacity
demyelination of the PNS: regeneration
axons/Schwann cells do have a limited regenerative capacity
How would you diagnose demyelination of the CNS?
- MRI: can see white matter lesions
- once they have symptoms, should be visible
How would you diagnose demyelination of the PNS?
EMG/NCV study
types of tracts
- ascending
- descending
ascending tracts
carry sensory information
descending tracts
carry motor information
What are tracts made of?
axons, usually myelinated
clusters of cell bodies in the CNS
nuclei
clusters of cell bodies in the PNS
ganglia
Why are clusters of cell bodies in the CNS called nuclei?
all the cells have a similar function
