1.20 Week 2:1 Flashcards
treatment of lead poisoning
chelation therapy
Why is lead poisoning so bad?
It’s a competitive inhibitor that mimics calcium, magnesium, etc. (2+)
lead poisoning neurological damage
irreversible
pro/con to chelation therapy
- can remove lead from the body
- not successful in children
What can Zika virus cause?
microcephaly
Zika virus: infection
- mosquito borne
- affects current pregnancy (not future ones)
- recently occurring a lot in Brazil
Zika virus: infection early in pregnancy
affects neural tube closing (and subsequent microcephaly)
Zika virus: infection later in pregnancy
Guillon-Barré
What if a child with microcephaly survive? What will they need?
likely need lifelong PT, OT, etc
demyelination: Which cells are affected in the CNS?
oligodendrocytes
demyelination: Which cells are affected in the PNS?
Schwann cell
early stage demyelination in CNS/PNS
appear similar in early stages
demyelination of the CNS: regeneration
doesn’t have much if any regenerative capacity
demyelination of the PNS: regeneration
axons/Schwann cells do have a limited regenerative capacity
How would you diagnose demyelination of the CNS?
- MRI: can see white matter lesions
- once they have symptoms, should be visible
