2. Diseases of the lungs and upper airways in ruminants Flashcards
Diseases in lungs (List)?
Nasal haemorrhage
Malignant catarrhal fever
Ibr
BVD
frontal sinusitis
larangeal paralysis
fog fever
enzootic bronchopneumonia of calves
lungworm disease
dry pleuritis
bronchitis and bronchopneumonia
Nasal haemorrhage?
Nasal haemorrhage
• Traumatic origin in the background of 99% of cases
Malignant catarrhal fever?
Malignant catarrhal fever- Herpesvirus
- OHV-2
- Transmission from sheep and goats kept in close contact
Clinical signs
- Depressed, dyspnoea, changes of mucous membranes
- *** Bilateral catarrhal discharge ***
- Salivation
- Necrotic changes on the nasal region with purulent discharge
IBR?
Infectious Bovine Rhinotracheitis (IBR)
- Bovine herpesvirus 1- BHV-1
- Vaccination is available
- Occurs after stress
Clinical signs
• Unilateral catarrhal chemosis
o Inflammation is so bad you can no longer see the eye of the animal
Diagnosis
• Laboratory exams
BVD?
Bovine Viral Diarrhoea (BVD)- Pestivirus
Clinical signs
- Respiratory signs and ulceration in the mouth
- Severe immune-depressive virus= many other diseases can arise with BVD as the primary infection
- Watery nasal discharge
Diagnosis
• Laboratory exams
Horn inflammation?
Horn inflammation/ frontal sinusitis
- Fighting
- Cutting by veterinary
- Frontal sinus cavity will become exposed
o Flies, insects, and bacteria can enter
§ = infection
Treatment
- AB less successful- poor circulation here
- Locally administered drugs are more useful
Laryngeal paralysis?
Laryngeal paralysis
• Fuel contaminated hay poisoned the cattle
Diagnosis
- Bronchoscopy
- Laryngoscopy
Fog fever cause and pathogenesis?
Fog fever
- Acute bovine pulmonary emphysema and oedema (ABPEE)
- 3-methyl indole
Pathogenesis
- The cows are fed on poor pasture then they are moved to and consume lush pasture
- They eat many hydrolysable proteins, this results in an increased ruminal NH3 content and decreased pH
- L- tryptophan is produced and metabolized into 3-methyl-indole, it goes to the liver and then to the lungs
- In the lungs there is biotransformation where it then acts on the phospholipid membrane
- = Alveolar epithel damage = increased permeability = oedema
Clinical signs and Diagnosis of fog fever?
Clinical signs
- After 4-10 days, sudden multiplied onset
- Only occur in adult animals
- Cyanosis
- HR + RR incr
- White foamy nasal discharge
o = Lung oedema
Diagnosis
• Detection of 3-methyl indole from the ruminal fluid
Differential diagnosis and diseases to rule out when sudden death occurs?
Differential diagnosis
- Severe rumen overload, Lactacidemia
- Bloat (free-gas, frothy)
- Poisonings
o Cyanic glycosides, methemoglobinemia
Diseases to rule out when sudden death occurs
- Clostridium perfringens toxaemia
- Electrical stroke
- Lightning strike
- Toxicoses
Treatment of fog fever?
Treatment
- Hay instead of grass
- AB PO to suppress bacteria producing ammonia
o Neomycin, tetracyclines
• 20-40% glucose infusion IV
o Treat lung oedema
- Antihistamines, GCC, flunixin meglumine
- Diuresis
o Furosemide IV
Enzootic bronchopneumonia in calves viral and bacterial causes?
Enzootic bronchopneumonia of Calves
- Multifactorial disease
- Did the calf get enough colostrum?
Viral
- PI-3
- Adeno
- BVD
- IBR
Bacterial
- Pasteurella haemolytica
- Pasteurella multocida
- Haemophilus somnus
- Mycoplasma bovis
Predisposing factors of enzootic bronchopneumonia?
Predisposing factors
- Dust
- Cold
- Gas- NH3
- Mycotoxins
- Trichophytiasis- ring worm
- Parasites
- Colostrum antibodies, nutrient, and vitamin deficiency
Enzootic bronchopneumonia pathogenesis?
Pathogenesis
- It begins with predisposing factors. These infections lead to respiratory epithelial damage
- From this damage there are 3 possibilities:
o Sudden death, this is the cheapest way, and the virus will not replicate in this animal
o Quick recovery- the best option
o Bacterial Infection
• From the 3rd possibility there is overgrowth of bacteria within the lower respiratory tract, and they produce
cytotoxins
• This leads to dysfunction of alveolar macrophages, overgrowth of bacteria (Pasteurella, haemophilia)
inflammation, finally resulting in sudden death, recovery, or chronic disease
• In the chronic disease there is huge loss of the lung surface leading to decreased oxygen intake and thus
decreased production. This is seen in the slaughterhouse/necropsy
Clinical signs of enzootic bronchopneumonia?
Clinical signs
• At the start:
o Depression but clean animal in good condition
o Slight nasal discharge
o Temperature is high
o If we examine the lung there is moisture movement
- If we take a swab, we will detect the virus/ bacteria
- As the disease progresses:
o There is more nasal discharge
• Chronic:
o Dyspnoea
o Small salivation
o Dull coat