Type II Hypersensitivity Reactions

Question 1

What are the 3 mechanisms for Type II reactions?

Answer 1

Phagocytosis
Inflammation
Cellular Dysfunction

Question 2

What are the 3 mechanisms for Type II reactions?

Answer 2

Phagocytosis
Inflammation
Cellular Dysfunction

Question 3

What occurs with the phagocytosis mechanism?

Answer 3

Opsonized cells leads to phagocytosis and removes the cells

Question 4

Direct lysis occurs with what instead of the phagocytosis mechanism?

Answer 4

Antibody-dependent cellular cytotoxicity

Question 5

What are 2 examples of diseases that use Type II phagocytosis mechanism?

Answer 5

Autoimmune Anemia and Thrombocytopenia

Question 6

Anemia and Thrombocytopenia used what mechanism for Type II?

Answer 6

Phagocytosis - decrease the cells!

Question 7

What 2 things are involved with the inflammation mechanism of Type II?

Answer 7

Fc receptor and complement

Question 8

With the inflammation mechanism, what do Fc receptor and complement increase?

Answer 8

Enzymes, neutrophils and ROS

Question 9

With the inflammation mechanism, increased enzymes, neutrophils and ROS does what?

Answer 9

Inflammation and TISSUE DAMAGE

Question 10

2 examples of Type II inflammation and tissue injury diseases?

Answer 10

Goodpasture syndrome

Rheumatic fever

Question 11

Antibodies that recognize basement membrane proteins that causes tissue damage

Answer 11

Goodpasture syndrome

Question 12

After strep throat, what can occur?

Answer 12

Molecular mimicry of the myocardial antigen that looks like the streptococcal antigen

Question 13

If the myocardial antigen looks like the streptococcal antigen, what will occur?

Answer 13

Antibodies will attack the myocardial antigen

Question 14

Symptoms of Rheumatic heart?

Answer 14

Valve vegetations and pericarditis

Question 15

When the myocardial antigen looks like the streptococcal antigen after a case of strep throat, what syndrome is that?

Answer 15

Rheumatic fever

Question 16

With the Cellular Dysfunction mechanism, what is happening?

Answer 16

Antibodies are blocking or stimulating the receptor

Question 17

With the Cellular Dysfunction mechanism, what is happening?

Answer 17

Antibodies are blocking or stimulating the receptor

Question 18

Myasthenia gravis

Answer 18

Type II cellular dysfunction

= Antibodies are blocking the Ach receptor

Question 19

Antibodies blocking the Ach receptor?

Answer 19

Myasthenia gravis

Question 20

Graves disease

Answer 20

Type II cellular dysfunction

= Antibodies are stimulating the TSH receptor

Question 21

Antibodies stimulating the TSH receptor?

Answer 21

Graves disease

Question 22

With Type II reactions, antibodies react to?

Answer 22

DIRECTLY to antigen/tissue