Benign Tumors of Infancy and Childhood (10) Flashcards
Heterotopia
Choristoma
- Normal tissue that is in an Abnormal location
Hamartoma
Normal tissue that is in its normal location but is weirdly organized (overgrowth)
What is the most common tumor of infancy?
Hemagioma
List 3 common benign tumors of infancy
Hemangioma
Fibrous tumors
Teratomas
Where are most hemangiomas located?
Face and scalp
What do hemangiomas look like?
Benign tumors on the face/scalp that are either flat or elevated red or blue masses
“port wine stain”
Hemangiomas!
How are hemangiomas treated?
They usually spontaneously regress
With what disease are hemangiomas occasionally associated with?
Von Hippel-Lindau
Von Hippel-Lindau Disease is associated with what childhood tumor?
Hemangiomas
What are the main familial CNS cavernous hemangioma genes?
KRIT1, CCM2, PCDC10
Fibrous tumors are proliferations of what cell shape?
Spindle
Fibrous tumors are almost identical to what adult tumor?
Fibrosarcoma
What is the most common teratoma?
Sacrococcygeal Teratoma
In what gender are Sacrococcygeal Teratomas more common?
4X more common in females
Sacrococcygeal Teratomas - histologically immature or mature?
Mature
Most common malignant neoplasm of infancy and childhood?
Leukemia
Survival rate of cancers - better for children or adults?
Children
Describe the histologic appearance of childhood cancers
- Undifferentiated cells
- Small round nuclei in cells in sheets
- Show features of organogenesis specific to site of tumor
How are many childhood cancers described histologically?
“small round blue cell tumors”
Why are childhood cancers give the “-blastoma” suffix?
They show organogenesis specific to the site of the tumor
How do the cells look in most childhood cancers?
Undifferentiated; Small cells aligned in a sheet with round nuclei
