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MOD > Autoimmune Diseases > Flashcards

Autoimmune Diseases Flashcards

1
Q

SLE (systemic lupus erythematosus) is associated with what type of autoantibodies?

A

“vast array”

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2
Q

What type of factors can cause someone to be more likely to develop SLE?

A

Family patterns, HLA-DQ
X chromosomes - females
UV light

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3
Q

HLA-DQ is associated with?

A

SLE

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4
Q

What immune mechanisms are involved with SLE?

A
  1. B cells and CD4+ T cells

2. Antigen-Antibody complex (Type III)

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5
Q

SLE has a tendency for what population?

A

Younger females

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6
Q

Physical exam finding for SLE?

A

Butterfly (Malar) rash on the face

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7
Q

Butterfly (malar) rash on the face is associated with?

A

SLE

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8
Q

What are some other symptoms of SLE?

A

Hemolytic - Anemia/Thrombocytopenia
Renal damage
Fatigue, Fever
Arthritis

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9
Q

Anemia, Renal damage, Arthritis, Fatigue, Fever?

A

SLE

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10
Q

Most common subtype of SLE?

A

Type IV (Diffuse Nephritis)

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11
Q

Are patients symptomatic and if so, list a few symptoms, with Diffuse Nephritis (IV)?

A

Yes - proteinuria, hematuria

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12
Q

What heart problem is associated with Diffuse Nephritis (IV)?

A

Libman-Sacks Endocarditis

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13
Q

What is Libman-Sacks Endocarditis?

A
  • Heart condition associated with Diffuse Nephritis
    = Fibrin deposits on the heart valves
    – Not infective, but can embolize
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14
Q

What artery disease are those with Diffuse Nephritis likely to get?

A

Coronary A. Disease

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15
Q

What cell is usually seen with SLE?

A

L-E cell

- Neutrophil/Macrophage that has ingested nucleus of a damaged cell

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16
Q

What is an L-E cell?

A

Neutrophil/Macrophage that has ingested nucleus of a damaged cell
- Seen with SLE/Diffuse Nephritis

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17
Q

What do Glomeruli show with Diffuse Nephritis?

A

Proliferation of cells and immune complex deposits

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18
Q

2 types of SLE?

A
  1. Discoid Lupus Erythematosus

2. Drug-Induced Lupus Erythematosus

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19
Q

Symptoms with Discoid Lupus Erythematosus?

A

Discoid rash on the face/scalp

20
Q

Discoid rash on the face/scalp

A

Discoid Lupus Erythematosus

21
Q

What tests will be (+)/(-) with Discoid Lupus Erythematosus?

A

(+) ANA
(+) Immunoflourescence
(-) Anti-DS DNA

22
Q

(+) ANA
(+) Immunofluorescence
(-) Anti-DS DNA

A

Discoid Lupus Erythematosus

23
Q

Symptoms with Drug-Induced Lupus Erythematosus?

A

Discoid rash, joint aches, fever, hematologic disease

24
Q

Symptoms with Drug-Induced Lupus Erythematosus?

A

Discoid rash, joint aches, fever, hematologic disease

25
Q

What causes Drug-Induced Lupus Erythematosus?

A

Medications

- Stop the medications and it will resolve

26
Q

What tests will be (+)/(-) with Drug-Induced Lupus Erythmatosus?

A

(+) ANA
(+) Immunofluorescence
(+) Anti-Histone Ab

27
Q

(+) Anti-Histone Antibody indicates?

A

Drug-Induced Lupus Erythematosus

28
Q

What occurs with Sjogren Syndrome?

A

Lacrimal and Salivary gland destruction

29
Q

Lacrimal and Salivary gland destruction

A

Sjogren Syndrome

30
Q

What cells are involved with Sjogren Syndrome and what will eventually result?

A

B and T cells cause inflammation and damage that will result in Fibrosis

31
Q

Anti-RO/ss-B and Anti-La/ss-A indicate?

A

Sjogren Syndrome

32
Q

Symptoms of Sjogren Syndrome?

A

Dry eye and Dry mouth with difficulty swallowing

33
Q

Dry eye and dry mouth with trouble swallowing is seen with?

A

Sjogren Syndrome

34
Q

Sjogren Syndrome causes dry mouth. What other things can be seen in the mouth?

A

Root caries

Smooth tongue with Candida yeast infection

35
Q

What other diseases can Sjogren Syndrome cause?

A

Pulmonary fibrosis

Lymphoma

36
Q

What is Systemic Sclerosis?

A

Fibrosis throughout the body, especially skin, GI, kidneys

37
Q

Fibrosis throughout the body with collagen deposition?

A

Systemic Sclerosis

38
Q

Main physical finding with Systemic Sclerosis?

A

Sclerodactyly

39
Q

What can Sclerodactyly progress to?

A

Raynauds - necrotic fingers

40
Q

Subtupe of Systemic Sclerosis?

A

CREST syndrome

41
Q

Symptoms of CREST syndrome?

A 
C - calcium deposits
R - raynaud fingers
E - esophageal dysfunction
S - sclerodactyly
T - telangiectasis
42
Q

Telangiectasis

A

Red marks on skin

- Seen with CREST syndrome

43
Q

Symptoms of CREST syndrome?

A 
C - calcium deposits
R - raynauds fingers
E - esophageal dysfunction
S - sclerodactyly
T - telangiectasis
44
Q

What do plasma cells produce with IgG4-related disease?

A

IgG4

45
Q

IgG4-related disease symptoms?

A
  • Fibrosis
  • Scarring
  • Irreversible damage
46
Q

IgG4-related disease affects?

A

Many organs and is a process used by many disease

47
Q

IgG4-related disease symptoms?

A
  • Fibrosis
  • Scarring
  • Irreversible damage

MOD (68 decks)

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