Gram (+) Bacteria - Bacilli Flashcards
Bacillus grow in what conditions?
O2 - Aerobic
Bacilli are what shape?
Rod shaped
What are the spore forming Bacilli?
Bacillus
Clostridium
What are the NON-spore forming Bacilli?
Corynebacterium
Listeria
Clostridium grows in what conditions?
NO O2 - Anaerobic
Attributes of Bacillus Cereus
Gram (+)
Spore forming
Aerobic rod
Spores are ____ resistant
Heat
What 2 toxins are involved with Bacillus Cereus?
Heat Stabile toxin
Heat Labile Toxin
Heat stabile toxin causes what, in association with Bacillus Cereus?
Emetic disease - vomiting
Heat labile toxin causes what, in association with Bacillus Cereus?
Diarrheal disease - watery
– Direct ingestion of bacteria
Attributes of Bacillus Anthracis
Gram (+)
Encapsulated
Anaerobic spore forming rod
Where is Bacillus Anthracis found?
Herbivore animal products (hides) and soil
Symptoms of Infection with Bacillus Anthracis?
Cutaneous - Malignant Pustule
Inhalation - Pulmonary spores that lead to mediastinal hemorrhage and death
What is the causative organism of antibiotic associated colitis?
Clostridium (Clostridiodes) Difficile
Clostridium (Clostridiodes) Difficile virulence toxins and symptoms?
A - Inflammation and diarrhea
B - Toxic to colonic epithelial cells
What are the physical findings with Clostridium (Clostridiodes) Difficile?
Pseudomembranous Colitis (exudative plaques)
What is the toxin mediated by Clostridium Botulinum?
Neurotoxin
Job of Neurotoxin with Clostridium Botulinum?
Inhibits release of Ach at the NMJ
Adult symptoms of Clostridium Botulinum?
Bilateral cranial neuropathies with descending muscle weakness
How does Clostridium Botulinum cause adult death?
Respiratory paralysis
Infant symptoms of Clostridium Botulinum?
Constipation, trouble swallowing and muscle weakness
What are sources of Clostridium Botulinum?
Canned food, smoked fish, honey, infant powder
What is the toxin mediated by Clostridium Tetani?
Neurotoxin
Job of Neurotoxin with Clostridium Tetani?
Inactivates Glycine and GABA
= Sustained contractions of motor neurons
Symptoms of Clostridium Tetani?
Muscle spasms (risus sardonicus, opisthotonos, lock jaw) and autonomic instability
Risus sardonicus
Face and neck muscle spasms
- seen with Clostridium Tetani
Opisthotonos
Arching of head and spine
- seen with Clostridium Tetani
Disease manifestations of Clostridium Perfringens
Wound infection
Myonecrosis
Purple/black skin with gas formation
= Gas gangrene and crepitus
What are 3 bacteria that are NON-spore forming Bacilli?
Corynebacterium Diptheriae
Rhodococcus Equi
Listeria Monocytogenes
Attributes of Corynebacterium Diptheriae?
Gram (+)
NON-spore forming Bacilli
Club shaped
Virulence factor of Corynebacterium Diptheriae?
AB Exotoxin
What is a hallmark of Corynebacterium Diptheriae?
Pharyngitis with Pseudomembrane formation
yellow/gray exudate in throat
What should you not do if a patient has pharyngitis with pseudomembrane formation caused by corynebacterium diptheriae?
DO NOT SCRAPE
– Will cause systemic absorption of toxin
Symptoms of systemic absorption of Corynebacterium Diptheriae?
Myocarditis - AV block
Neural Involvement
Attributes of Rhodococcus Equi?
Gram (+) Pleomorphic
NON-spore forming Bacilli
Club shaped
Symptoms of Rhodococcus Equi?
Cavities with air-fluid level in upper lung
Pulmonary disease in immunocompromised
Attributes of Listeria Monocytogenes?
Gram (+)
NON-spore forming
Describe the unique features of Listeria Monocytogenes
Grows at cooler temperatures - 4-10 degrees celsius
Flagella with tumbling motility at 25 degrees celsius
Who is at high risk for Listeria infection?
Pregnant women
Listeria Monocytogenes is found where?
Dairy products and meat
Listeria symptoms of fetus?
Granulomatous Infantiseptica and meningitis
Listeria symptoms of mother?
Sepsis
Listeria symptoms of elderly?
Meningitis