Transplant Rejection Flashcards

1
Q

2 types of Allorecognition?

A

Donor Graft APC

Recipient APC

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2
Q

2 categories of Rejection?

A

Humoral

Cell-mediated

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3
Q

Humoral Rejection is mediated by?

A

Antibodies

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4
Q

Cell-mediated Rejection is mediated by?

A

T cells

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5
Q

How quickly does Hyperacute Rejection occur?

A

Minutes to hours

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6
Q

Describe Hyperacute Rejection

A
  • Preformed antibodies cause inflammation

- Thrombotic Microvasculopathy

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7
Q

What usually causes Hyperacute Rejection?

A

ABO blood group antigens

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8
Q

What type of Rejection is Hyperacute Rejection?

A

Humoral

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9
Q

What occurs with Acute/Chronic Antibody - mediated Rejection?

A

Inflammation with complement C4d breakdown product

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10
Q

Inflammation with complement C4d breakdown product is what type of rejection?

A

Acute/Chronic Antibody-mediated Rejection

Humoral

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11
Q

What stain will be positive with Acute/Chronic Antibody-mediated Rejection?

A

C4d stain (+)

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12
Q

C4d stain (+)

A

Acute/Chronic Antibody-mediated Rejection

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13
Q

What does Chronic Cellular rejection cause?

A

Arteriosclerosis

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14
Q

Arteriosclerosis from Rejection is what type?

A

Chronic Cellular Rejection

T cell mediated

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15
Q

T cell mediated Rejections?

A

Acute and Chronic Cellular Rejections

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16
Q

Acute and Chronic Cellular Rejections are what cell mediated?

A

T cell

17
Q

When treating patients after a transplant, what are they are risk for?

A

INFECTIONS

18
Q

Common viral infections that post-transplant patients are at risk for?

A

Polyomavirus

Cytomegalovirus

19
Q

What is an Hematopoietic Stem Cell Transplant?

A

Giving a patient a NEW immune system by destroying their bone marrow

20
Q

Destroying ones bone marrow to inject stem cells creates?

A

NEW immune system

hematopoietic stem cell transplant

21
Q

What is a Graft Vs. Host Disease?

A

T lymphocytes in transplant tissue attacking the host

22
Q

What is a Graft Vs. Host Disease?

A

T lymphocytes in the transplanted tissue attacking the host

23
Q

What are the symptoms of a Graft Vs. Host Disease?

A

Rash, Jaundice, Bloody Diarrhea

24
Q

Rash, Jaundice, Bloody Diarrhea can indicate?

A

Graft vs. Host Disease