Transplant Rejection Flashcards
2 types of Allorecognition?
Donor Graft APC
Recipient APC
2 categories of Rejection?
Humoral
Cell-mediated
Humoral Rejection is mediated by?
Antibodies
Cell-mediated Rejection is mediated by?
T cells
How quickly does Hyperacute Rejection occur?
Minutes to hours
Describe Hyperacute Rejection
- Preformed antibodies cause inflammation
- Thrombotic Microvasculopathy
What usually causes Hyperacute Rejection?
ABO blood group antigens
What type of Rejection is Hyperacute Rejection?
Humoral
What occurs with Acute/Chronic Antibody - mediated Rejection?
Inflammation with complement C4d breakdown product
Inflammation with complement C4d breakdown product is what type of rejection?
Acute/Chronic Antibody-mediated Rejection
Humoral
What stain will be positive with Acute/Chronic Antibody-mediated Rejection?
C4d stain (+)
C4d stain (+)
Acute/Chronic Antibody-mediated Rejection
What does Chronic Cellular rejection cause?
Arteriosclerosis
Arteriosclerosis from Rejection is what type?
Chronic Cellular Rejection
T cell mediated
T cell mediated Rejections?
Acute and Chronic Cellular Rejections
Acute and Chronic Cellular Rejections are what cell mediated?
T cell
When treating patients after a transplant, what are they are risk for?
INFECTIONS
Common viral infections that post-transplant patients are at risk for?
Polyomavirus
Cytomegalovirus
What is an Hematopoietic Stem Cell Transplant?
Giving a patient a NEW immune system by destroying their bone marrow
Destroying ones bone marrow to inject stem cells creates?
NEW immune system
hematopoietic stem cell transplant
What is a Graft Vs. Host Disease?
T lymphocytes in transplant tissue attacking the host
What is a Graft Vs. Host Disease?
T lymphocytes in the transplanted tissue attacking the host
What are the symptoms of a Graft Vs. Host Disease?
Rash, Jaundice, Bloody Diarrhea
Rash, Jaundice, Bloody Diarrhea can indicate?
Graft vs. Host Disease
