Transplant Rejection Flashcards
2 types of Allorecognition?
Donor Graft APC
Recipient APC
2 categories of Rejection?
Humoral
Cell-mediated
Humoral Rejection is mediated by?
Antibodies
Cell-mediated Rejection is mediated by?
T cells
How quickly does Hyperacute Rejection occur?
Minutes to hours
Describe Hyperacute Rejection
- Preformed antibodies cause inflammation
- Thrombotic Microvasculopathy
What usually causes Hyperacute Rejection?
ABO blood group antigens
What type of Rejection is Hyperacute Rejection?
Humoral
What occurs with Acute/Chronic Antibody - mediated Rejection?
Inflammation with complement C4d breakdown product
Inflammation with complement C4d breakdown product is what type of rejection?
Acute/Chronic Antibody-mediated Rejection
Humoral
What stain will be positive with Acute/Chronic Antibody-mediated Rejection?
C4d stain (+)
C4d stain (+)
Acute/Chronic Antibody-mediated Rejection
What does Chronic Cellular rejection cause?
Arteriosclerosis
Arteriosclerosis from Rejection is what type?
Chronic Cellular Rejection
T cell mediated
T cell mediated Rejections?
Acute and Chronic Cellular Rejections