Mediators of Inflammation (3) Flashcards
What secretes Histamine?
Mast Cells
Basophils
Platelets
3 actions of Histamine?
VASODILATION
Increased vascular permeability
Endothelial activation
Prostaglandins and Leukotrienes are produced from?
Arachidonic Acid
Arachidonic Acid creates _____ to create Prostaglandins
Cyclooxygenase
3 actions of Prostaglandins?
Vasodilation
Fever
Pain
What can inhibit Cyclooxygenase and thus prostaglandin formation?
COX inhibitors
Arachidonic Acid creates _____ to create Leukotrienes
5-lipoxygenase
2 actions of Leukotrienes?
Bronchospasm
Increased Vascular permeability
5-lipoxygenase can create 12-lipoxygenase to create ____
Lipoxins
Action of Lipoxins?
INHIBIT NEUTROPHIL adhesion and chemotaxis
TNF action
Increase Adhesion molecules
IL-1 actions
Increase Adhesion molecules
Fever
IL-17 action
Recruit neutrophils and monocytes
IL-12 action
Increase production of IFNgamma
IFNgamma action
Activate macrophages
Proteins that act as chemoattractants for leukocytes
Chemokines
What activates C3 in the complement cascade?
C3 convertase
Actions of the complement cascade
Increased vascular permeability
Phagocytosis
Chemotaxis
What controls the complement system?
C1 inhibitor
If there is a deficiency in C1 inhibitor, what results?
Hereditary Angioedema
Serous Inflammation
Cell poor fluid into spaces (NO microbes or leukocytes)
Fibrinous Inflammation
Large molecules can pass through the endothelium due to increased permeability
Fibrinous Inflammation is characteristic infammation of?
Inflammation of lining of body cavities
Purulent Inflammation
Production of pus (neutrophils, cell debris, microbes)
Purulent Inflammation is seen with what type of necrosis?
Liquefactive
Pyogenic
Pus producing bacteria
Ulcer
Sloughing of inflamed necrotic tissue
3 outcomes of Acute Inflammation?
- Resolution
- Fibrosis = loss of function
- Chronic Inflammation
Fibrosis
Loss of function
