Mediators of Inflammation (3)

Question 1

What secretes Histamine?

Answer 1

Mast Cells
Basophils
Platelets

Question 2

3 actions of Histamine?

Answer 2

VASODILATION
Increased vascular permeability
Endothelial activation

Question 3

Prostaglandins and Leukotrienes are produced from?

Answer 3

Arachidonic Acid

Question 4

Arachidonic Acid creates _____ to create Prostaglandins

Answer 4

Cyclooxygenase

Question 5

3 actions of Prostaglandins?

Answer 5

Vasodilation
Fever
Pain

Question 6

What can inhibit Cyclooxygenase and thus prostaglandin formation?

Answer 6

COX inhibitors

Question 7

Arachidonic Acid creates _____ to create Leukotrienes

Answer 7

5-lipoxygenase

Question 8

2 actions of Leukotrienes?

Answer 8

Bronchospasm

Increased Vascular permeability

Question 9

5-lipoxygenase can create 12-lipoxygenase to create ____

Answer 9

Lipoxins

Question 10

Action of Lipoxins?

Answer 10

INHIBIT NEUTROPHIL adhesion and chemotaxis

Question 11

TNF action

Answer 11

Increase Adhesion molecules

Question 12

IL-1 actions

Answer 12

Increase Adhesion molecules

Fever

Question 13

IL-17 action

Answer 13

Recruit neutrophils and monocytes

Question 14

IL-12 action

Answer 14

Increase production of IFNgamma

Question 15

IFNgamma action

Answer 15

Activate macrophages

Question 16

Proteins that act as chemoattractants for leukocytes

Answer 16

Chemokines

Question 17

What activates C3 in the complement cascade?

Answer 17

C3 convertase

Question 18

Actions of the complement cascade

Answer 18

Increased vascular permeability
Phagocytosis
Chemotaxis

Question 19

What controls the complement system?

Answer 19

C1 inhibitor

Question 20

If there is a deficiency in C1 inhibitor, what results?

Answer 20

Hereditary Angioedema

Question 21

Serous Inflammation

Answer 21

Cell poor fluid into spaces (NO microbes or leukocytes)

Question 22

Fibrinous Inflammation

Answer 22

Large molecules can pass through the endothelium due to increased permeability

Question 23

Fibrinous Inflammation is characteristic infammation of?

Answer 23

Inflammation of lining of body cavities

Question 24

Purulent Inflammation

Answer 24

Production of pus (neutrophils, cell debris, microbes)

Question 25

Purulent Inflammation is seen with what type of necrosis?

Answer 25

Liquefactive

Question 26

Pyogenic

Answer 26

Pus producing bacteria

Question 27

Ulcer

Answer 27

Sloughing of inflamed necrotic tissue

Question 28

3 outcomes of Acute Inflammation?

Answer 28

1. Resolution
2. Fibrosis = loss of function
3. Chronic Inflammation

Question 29

Fibrosis

Answer 29

Loss of function