DNA Virus - Herpesvirus Flashcards
A virus is an infectious agent that contain?
Either DNA or RNA
Viruses require what type of cells?
Living cells for energy
Viruses - intracellular or extracellular?
Intracellular
How big are viruses?
TINY
What are the DNA Viruses?
HHAPPPy
- Herpesvirus
- Hepadnavirus
- Adenovirus
- Papovavirus
- Parvovirus
- Poxvirus
What are the DNA Viruses?
HHAPPPy
- Herpesvirus
- Hepadnavirus
- Adenovirus
- Papovavirus
- Parvovirus
- Poxvirus
What are the DNA Viruses?
HHAPPPy
- Herpesvirus
- Hepadnavirus
- Adenovirus
- Papovavirus
- Parvovirus
- Poxvirus
What are the main Herpesviruses?
Herpes Simplex Viruses 1 and 2 Varicella - Zoster Virus Epstein - Barr Virus Cytomegalovirus Roseola (HHV-6) HHV-8
How are Herpes Simplex Viruses 1 and 2 spread?
Skin-to-skin contact
Herpes Simplex Virus (HSV) 1 involves what part of the body?
Orofacial
Herpes Simplex Virus (HSV) 2 involves what part of the body?
Genital
What are common orofacial and finger infections seen with Herpes Simplex Virus?
Gingivostomatitis (orofacial involvement) Herpetic Whitlow (finger infection)
Herpes Simplex Viruses 1 and 2 are causes of neonatal infection/death and are a part of the?
TORCH
What is the number 1 cause of encephalitis (inflammation of the brain)?
Herpes Simplex Virus
2 diseases caused by the Varicella-Zoster Virus?
Chickenpox (Varicella)
Shingles (Herpes Zoster)
The Varicella portion of the Varicella-Zoster Virus affects who how?
Children
- Aerosolized transmission and skin-to-skin transmission
How long is the incubation period for the Varicella portion of the Varicella-Zoster Virus?
2 weeks
Symptoms of Chickenpox (Varicella)?
Rash: Papules -> Vesicles -> Scabs
Fever, malaise
How does one get Shingles (Herpes Zoster)?
Reactivation of latent infection in the DRG
Symptoms of Shingles (Herpes Zoster)?
Painful, burning lesion in dermatomal distribution
What determines where the lesion will be with Shingles (Herpes Zoster)?
Dermatome!
How is Epstein-Barr Virus spread?
Saliva, toothbrushes, kissing, utensils
What population and cells does the Epstein - Barr Virus affect?
Young adults
- AFFECTS B CELLS
Via ____ receptor, Epstein - Barr virus affects B cells directly
C3d
What does the Epstein - Barr virus cause and what are the symptoms?
Sore throat
Fever
Lymphadenopathy
Hepatosplenomegaly
What cancers are those with the Epstein - Barr virus at risk for?
B cell lymphomas
Nasopharyngeal carcinomas
How do lymphocytes look with Epstein - Barr virus?
Atypical - MORE cytoplasm
What tests and when do you do them for the Epstein - Barr virus?
Heterophile Ab test (monospot)
– IF NEGATIVE –
EBV Ab test
With Cytomegalovirus, most are?
Asymptomatic
CMV Mononucleosis
Symptoms similar to EBV mononucleosis + GREATER FEVER!!!
- caused by cytomegalovirus
What is caused in the immunocompromised if cytomegalovirus is reactivated?
Chorioretinitis
= Blurry vision and floaters
Cytomegalovirus is a ____ disease because it causes congenital intellectual disability
TORCH
HHV - 6
Roseola
In what age group and what are the symptoms of Roseola (HHV-6)?
In children
= 3-5 days of high fever -> resolves -> RASH
3-5 days of high fever -> resolves -> RASH
Roseola (HHV-6)
What does HHV-8 cause?
Kaposi - Sarcoma
= vascular tumor
Symptoms of Kaposi - Sarcoma?
Red/purple skin nodules
– caused by HHV-8
In what populations is Kaposi - Sarcoma common?
- Caused by HHV - 8
= Males with AIDS, in middle east and Africa
