modules 2,4,5 synch session

Question 1

how does ibuprofen reduce pain

Answer 1

inhibits the action of COX and PG production

Question 2

how does NSAIDs contribute to gastric bleeding

Answer 2

local COX1 inhibition prevents the cytoprotective effects of prostaglandins on the gastric lining.

Question 3

how do corticosteroids affect the arachidonic acid pathway

Answer 3

inhibiting phospholipase A2

Question 4

What is the drug of choice for acute gout?

Answer 4

NSAID

Question 5

How does allopurinal prevent gout

Answer 5

prevents uric acid production

Question 6

how does probenecid prevent gout

Answer 6

dec. urate reabsorption in the PCT

Question 7

why do we not use allopurinal or probenecid during acute flare

Answer 7

precipitate urate kidney stone

Question 8

Which corticosteroid has highest mineralcorticoid activity

Answer 8

hydrocortisone

- 1:1 glucocorticoid to mineralcorticoid

Question 9

Use caution with mineralcorticoid activity in patient with what conditions

Answer 9

CHF

HTN

Question 10

H1 histamine receptor

Answer 10

smooth muscle 
vascular endothelium 
brain
- inc. production of nasal and bronchial mucus 
- bronchioconstriction 
- intestinal cramps and diarrhea
- itching and pain

Question 11

H2 receptor

Answer 11

gastric parietal cells
cardiac muscle
mast cells 
brain
- inc. hydrochloric acid secretion

Question 12

H3 receptor

Answer 12

CNS some peripheral nerves

Question 13

H4 receptor

Answer 13

hematopoietic cells

gastric mucosa

Question 14

H1 antihistamines MOA

Answer 14

inverse agonist

Question 15

NSAID and drug interactions

Answer 15

displaces other protein bound meds