module 6 cholinergic agonists

Question 1

cholinergic receptors

Answer 1

M1: autonomic ganglia, CNS
M2: cardiac muscle
M3: smooth mucsle, glandular tissues
M4: CNS
M5: CNS
-> MUSCARINIC

Nm: skeletal muscle at NMJ
Nn: autonomic ganglia, adrenal medulla, CNS
-> NICOTINIC

Question 2

ACh effects on muscarinic receptors: vasculature

Answer 2

release of NO and vasodilation

Question 3

ACh effects on muscarinic receptors: eye iris (pupil muscle)

Answer 3

contraction and miosis

Question 4

ACh effects on muscarinic receptors: ciliary muscle

Answer 4

thin and watery secretion

Question 5

ACh effects on muscarinic receptors: salivary and lacrimal glands

Answer 5

release of NO and vasodilation

Question 6

ACh effects on muscarinic receptors: bronchi

Answer 6

constriction

inc. secretions

Question 7

ACh effects on muscarinic receptors: heart

Answer 7

dec. HR
dec. conduction rate
AV block at high doses
dec. contractility

Question 8

ACh effects on muscarinic receptors: GI tract

Answer 8

inc. tone
inc. secretions
relaxation of sphincters

Question 9

ACh effects on muscarinic receptors: Urinary bladder

Answer 9

contraction of detrusor muscle

relaxation of sphincter

Question 10

ACh effects on muscarinic receptors: sweat glands

Answer 10

diaphoresis

Question 11

ACh effects on muscarinic receptors: reproductive tract; male

Answer 11

erection

Question 12

AChE inhibitors

Answer 12

inc. concentration of ACh in synapse
- inc. transmission at Nm junction
- inc. PSNS tone
- inc. central cholinergic activity

Question 13

AChE inhibitor and glaucoma

Answer 13

inc. outflow of aqueous humor

Question 14

AChE inhibitor and abd. distention

Answer 14

inc. smooth muscle motility

Question 15

AChE inhibitor adverse effect

Answer 15

inc. ACh
- N/V
- diarrhea
- anorexia
- flatulence
- abd. cramping

Question 16

muscarinic agonists

Answer 16

dx asthma
miosis and dec. intraocular pressure
GI and GU motility inc.

Question 17

nicotinic agonists

Answer 17

succinylcholine
resistant to AChE
induction of paralysis by means of depolarizing blockade

Question 18

muscarinic antagonists

Answer 18

allow sympathetic responses to dominate

Question 19

muscarinic antagonists adverse effects

Answer 19

anti-cholinergic

• blurred vision
• dry mouth
• ileus
• urinary retention
• flushing
• agitation
• tachycardia

Question 20

Nicotinic Antagonists

Answer 20

prevent andogenous ACh binding to nicotinic receptors and subsequent muscle cell depolarization
paralysis

Question 21

AChE inhibitors use

Answer 21

inc. levels of ACh
myasthenia gravis
glaucoma
alzheimers

Question 22

Nicotine agonists and antagonists use

Answer 22

neuromuscular paralyzing agents

Question 23

muscarinic agonist use

Answer 23

dx asthma
GI/GU motility
dec. intraocular pressure

Question 24

muscarinic antagonist use

Answer 24

motion sickness
bronchodilator 
overactive bladder
bradycardia 
mydriasis