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Pharmacology > module 6 cholinergic agonists > Flashcards

module 6 cholinergic agonists Flashcards

1
Q

cholinergic receptors

A 
M1: autonomic ganglia, CNS
M2: cardiac muscle
M3: smooth mucsle, glandular tissues
M4: CNS
M5: CNS
-> MUSCARINIC

Nm: skeletal muscle at NMJ
Nn: autonomic ganglia, adrenal medulla, CNS
-> NICOTINIC

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2
Q

ACh effects on muscarinic receptors: vasculature

A

release of NO and vasodilation

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3
Q

ACh effects on muscarinic receptors: eye iris (pupil muscle)

A

contraction and miosis

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4
Q

ACh effects on muscarinic receptors: ciliary muscle

A

thin and watery secretion

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5
Q

ACh effects on muscarinic receptors: salivary and lacrimal glands

A

release of NO and vasodilation

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6
Q

ACh effects on muscarinic receptors: bronchi

A

constriction

inc. secretions

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7
Q

ACh effects on muscarinic receptors: heart

A

dec. HR
dec. conduction rate
AV block at high doses
dec. contractility

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8
Q

ACh effects on muscarinic receptors: GI tract

A

inc. tone
inc. secretions
relaxation of sphincters

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9
Q

ACh effects on muscarinic receptors: Urinary bladder

A

contraction of detrusor muscle

relaxation of sphincter

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10
Q

ACh effects on muscarinic receptors: sweat glands

A

diaphoresis

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11
Q

ACh effects on muscarinic receptors: reproductive tract; male

A

erection

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12
Q

AChE inhibitors

A

inc. concentration of ACh in synapse
- inc. transmission at Nm junction
- inc. PSNS tone
- inc. central cholinergic activity

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13
Q

AChE inhibitor and glaucoma

A

inc. outflow of aqueous humor

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14
Q

AChE inhibitor and abd. distention

A

inc. smooth muscle motility

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15
Q

AChE inhibitor adverse effect

A

inc. ACh
- N/V
- diarrhea
- anorexia
- flatulence
- abd. cramping

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16
Q

muscarinic agonists

A

dx asthma
miosis and dec. intraocular pressure
GI and GU motility inc.

17
Q

nicotinic agonists

A

succinylcholine
resistant to AChE
induction of paralysis by means of depolarizing blockade

18
Q

muscarinic antagonists

A

allow sympathetic responses to dominate

19
Q

muscarinic antagonists adverse effects

A

anti-cholinergic

  • blurred vision
  • dry mouth
  • ileus
  • urinary retention
  • flushing
  • agitation
  • tachycardia
20
Q

Nicotinic Antagonists

A

prevent andogenous ACh binding to nicotinic receptors and subsequent muscle cell depolarization
paralysis

21
Q

AChE inhibitors use

A

inc. levels of ACh
myasthenia gravis
glaucoma
alzheimers

22
Q

Nicotine agonists and antagonists use

A

neuromuscular paralyzing agents

23
Q

muscarinic agonist use

A

dx asthma
GI/GU motility
dec. intraocular pressure

24
Q

muscarinic antagonist use

A 
motion sickness
bronchodilator 
overactive bladder
bradycardia 
mydriasis

Pharmacology (78 decks)

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