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Pharmacology > module 3 SNRI, atypical antiD, serotonin receptor agonist > Flashcards

module 3 SNRI, atypical antiD, serotonin receptor agonist Flashcards

1
Q

SNRI drugs

A

venlafaxine

duloxetine

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2
Q

SNRI MOA

A

block NE and 5HT reuptake

- venlafaxine: concentration dependent

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3
Q

SNRI use

A

depression

- duloxetine: also neuropathic pain

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4
Q

SNRI contraindication

A

HTN

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5
Q

duloxetine interactions

A

CYP2D6, 1A2

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6
Q

venlafaxine prodrug

A

desvenlafaxine active form

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7
Q

bupropion MOA

A

atypical antidepressant

inhibit dopamine and NE reuptake

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8
Q

bupropion AE

A

insomnia

least sexual side effects

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9
Q

bupropion contraindications

A

seizure disorder

eating disorder

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10
Q

bupropion administration

A

IR:TID
SR: BID
XL: daily

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11
Q

mirtazapine MOA

A

atypical antidepressant
antagonizes 5HT2/3 and a2 adrenergic receptors
antagonizes histamine

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12
Q

mirtazapine AE

A

inc. appetite
sedation
less sexual dysfunction

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13
Q

mirtazapine interactions

A

CYP3A4

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14
Q

Nefazodone MOA

A 
atypical antidepressant
inhibits 5HT transporter
antagonize:
-5HT2
- Histamine
- A1
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15
Q

nefazodone use

A

depression
anti-anxiety
- 2nd or 3rd line drug

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16
Q

nefazodone AE

A 
sedation
orthostasis
hepatotoxicity
fulminant liver failure
less sexual dysfunction
17
Q

nefazodone contra

A

liver dysfunction

18
Q

nefazodone interaction

A

CYP3A4

19
Q

trazodone MOA

A 
atypical antidepressant
inhibit 5HT transporter 
antagonize: 
- 5HT2
- histamine
- A1
20
Q

trazodone AE

A

priapism

21
Q

trazodone use

A

high dose: antidepressant

low dose: sleep agent

22
Q

trazodone interactions

A

CYP3A4

23
Q

buspirone MOA

A

serotonin receptor agonist
- 5HT1A
nonsedating
nonaddictive

24
Q

buspirone use

A

anxiety

25
Q

buspirone AE

A

dizzy

nausea

26
Q

drugs that inc. neurotransmission without known MOA

A

ampthetamine
methamphetamine
methylphenidate
modafinil
armodafinil
- may interfere with synaptic vesicle storage
- may displace 5HT, NE, DA from vesicles and reuptake

2nd line

27
Q

unknown MOA drugs AE

A

induction os psychosis and alertness

- use: narcolepsy

28
Q

lithium MOA

A

interfere with cAMP and IP3 formation

29
Q

lithium use

A

bipolar

- mania and depression control

30
Q

lithium AE

A 
nausea
thirst
polyuria
hypothyroidism 
tremor
weakness
confusion
teratogenesis
31
Q

lithium contra

A

narrow TI
preg
renal insufficiency
- secreted and reabsorbed in renal tubules

32
Q

lithium interactions

A

diuretics

probenecide

33
Q

lithium monitoring

A

therapeutic levels: 07-1.2.

34
Q

lithium administration

A

long half life: 12-27hrs

35
Q

Mood stabilizers for bipolar disorder

A

carbamazepine

valproic acid

Pharmacology (78 decks)

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