module 14 HRT androgen and phosphodiesterase 5 inhibitors

Question 1

testosterone enanthate/cypionate use

Answer 1

hypogonadism

- decreased testosterone levels

Question 2

testosterone enanthate/cypionate admin

Answer 2

Depo IM
-gradual release of oil-based vehicle
peak and trough

Question 3

testosterone enanthate/cypionate AE

Answer 3

mood fluctuation
energy fluctuation
libido fluctuation

Question 4

androgen replacement AE

Answer 4

abuse in athletes
erythrocytosis
suppress HPA axis
- possible infertility
- gynecomastia
- inc. lipids
risk to children and pets
- penile enlargelment
- pubic hair
- advanced bone age
- aggressive
- inc. libido

Question 5

topical gel and testosterone patch meds

Answer 5

gel: androgel
patch: androdrem

Question 6

androgel/androderm admin

Answer 6

stable testosterone levels

Question 7

androgel/androderm AE

Answer 7

skin irritation

Question 8

androgel/androderm EDU

Answer 8

relatively stable mood, energy, and libido

Question 9

phosphodiasterase type 5 (PDE5) inhibitor meds

Answer 9

sildenafil
vardenafil
tadalafil

Question 10

PDE5 inhibitor MOA

Answer 10

inhibit PDE5 in corpus cavernosum and pulmonary vasculature

• > inc. cGMP
• > smooth muscle relaxation and blood inflow

Question 11

PDE5 use

Answer 11

erectile dysfunction

pulmonary arterial HTN

Question 12

PDE5 AE

Answer 12

HA
flushing
MI
sudden death

Question 13

PDE5 DI

Answer 13

nitrates: severe hypotension