module 16 hyperglycemia management and CV impact Flashcards
1
Q
antihyperglycemic drug consideratoins
A
efficacy: A1C reduction propensity to cause hypoglycemia effect on weight: gain, loss, or neutral CV effects renal effects
2
Q
Monotherapy
A
metformin
- high efficacy
- low risk hypoglycemia
- neutral/ weight loss
3
Q
dual therapy
A
metformin +
- sulfonylurea
- thiazolidinedione
- DDP-4 inhibitor
- SGLT2 inhibitor
- GLP-1 agonist
- insulin
4
Q
triple therapy
A
metformin + 2 from dual therapy
5
Q
combo injectable therapy
A
metformin +
basal insulin +
mealtime insulin or GLP-1 agonist
6
Q
MACE
A
major adverse cardiovascular events
- studied with DM drugs
7
Q
alpha-glucosidase inhibitor CV impact
A
acarbose: neutral
meglitol: unknown
8
Q
amylin analong CV impact
A
pramlintide: unknown
9
Q
metformin CV impact
A
improved CV outcomes
10
Q
DPP-4 inhibitors CV impact
A
neutral
11
Q
GLP-1 agonist CV impact
A
improved CV outcome - albiglutide - dulaglutide - liraglutide - semaglutide neutral - exenatide - lixisenatide
12
Q
insulin CV impact
A
neutral
13
Q
meglitidines CV impact
A
unknown
14
Q
SGLT-2 inhibitor CV impact
A
improved CV outcomes - canagliflozin - dapagliflozin -empagliflozin Unknown - ertugliflozin
15
Q
suflonylureas CV impact
A
neutral - glimepride unknown - glipizide - glyburide
