module 16 non-insulin meds

Question 1

sulfonylurea meds

Answer 1

glyburide
glipizide
glimeperide

Question 2

sulfonylurea MOA

Answer 2

stimulate pancreatic insulin secretion
block ATP-sensitive K channels
-> depolarization -> Ca influx -> insulin release

Question 3

sufonylurea admin

Answer 3

hepatically metabolized

- parent and active metabolite renally excreted

Question 4

sulvonylurea AE

Answer 4

hypoglycemia

wt gain

Question 5

sulfonylurea EDU

Answer 5

moderate-high A1C reducation: >1%
- good efficacy: short lived (combo therapy)
renal dysfunction/elderly: glipizide is drug of choice: short half life.

Question 6

meglitinides meds

Answer 6

nateglinide

repaglinide

Question 7

meglitinide MOA

Answer 7

stimulates pancreatic insulin secretion

Question 8

meglitinide AE

Answer 8

hypoglycemia

wt gain

Question 9

meglitinide admin

Answer 9

rapid oral absorption
short half life
- freq. dosing
- with meals

Question 10

DDP-4 inhibitors meds

Answer 10

alogliptan
linagliptan
saxagliptan
sitagliptan

Question 11

DDP-4 inhibitors MOA

Answer 11

inc. incretin action
- > inc. glucose dependent insulin release
- > dec. post-prandial glucagon release

Question 12

DDP-4 nml activity

Answer 12

inactivates incretin

Question 13

DDP-4 inhibitor AE

Answer 13

URI
nasopharyngitis
low risk hypoglycemia
rare: pancreatitis

Question 14

DDP-4 inhbitor precaution

Answer 14

dose adjustment with renal impairment

Question 15

DDP-4 inhibitor DI

Answer 15

3A4: saxagliptan, linagliptan

Question 16

DDP-4 inhibitor EDU

Answer 16

modest A1C reduction: less than 1%

weight neutral

Question 17

GLP-1 agonist meds

Answer 17

gulaglutide
exenatide
liraglutide
lixisenatide
semaglutide

Question 18

GLP-1 agonist MOA

Answer 18

inc. incretin action
- activate GLP-1 Rc: inc. insulin, dec. glucagon
resistant to metabolism by DPP-4

Question 19

GLP-1 agonist AE

Answer 19

nausea
diarrhea
rare: pancreatitis
low risk hypoglycemia

Question 20

GLP-1 agonist admin

Answer 20

subQ

Question 21

GLP-1 agonist EDU

Answer 21

cardiovascular benefits
wt. loss
- slows gastric emptying
- dec. appetite
moderate A1C reduction: ~1%