module 3 antiemetics

Question 1

patho of emesis

Answer 1

midbrain contains high concentrations of emetogenic receptors

• dopamine D2 receptors
• muscarininc-cholinergic
• histamine
• 5HT3

Question 2

Rx with affinity for dopamine receptors

Answer 2

antagonize dopamine

• benzamides
• butyrophenones
• phenothiazines

Question 3

5HT3 antagonist

Answer 3

highly bound to 5HT3 receptors both centrally and peripherally

Question 4

corticosteroids

Answer 4

dexamethasone

- prevent chemotherapy induced N/V

Question 5

anticholinergics

Answer 5

block cholinergic muscarinic receptors

Question 6

antihistamines

Answer 6

act directly on the vomiting center and vestibular pathways

Question 7

phenothizaine drugs

Answer 7

chlorpromazine
prochlorperazine
promethazine
- cheap, inc. AE, dec. efficacy

Question 8

phenothiazine receptor site affinity

Answer 8

D2: ++++
muscarinic-cholinergic: ++
histamine: +++
serotonin: +/-

Question 9

butyrophenones

Answer 9

droperidol

haloperidol

Question 10

butyrophenones receptor site affinity

Answer 10

D2: ++++
muscarininic-cholinergic: -
histamine: +
serotonin: +/-

Question 11

benzamides

Answer 11

metoclopramide:
promote gut motility
gastroparesis

Question 12

corticosteroids

Answer 12

bethamethasone

dexamethasone

Question 13

anticholinergic

Answer 13

scopolamine
meclizine
- motion sickness

Question 14

anticholinergic receptor site affinity

Answer 14

D2: +
muscarininc-cholinergic: ++++
histamine: +
serotonin: -

Question 15

antihistamines

Answer 15

cyclizine
hydroxyzine
diphenhydramine

Question 16

antihistamine receptor site affinity

Answer 16

D2: +
muscarinic-cholinergic: ++
histamine: ++++
serotonin: -

Question 17

5HT3 antagonist

Answer 17

ondansetron
dolasetron
granisetron

Question 18

5HT3 antagonist receptor affinity

Answer 18

D2: -
muscarinic-cholinergic: -
histamine: -
serotonin: ++++

Question 19

Tricyclic antidepressant receptor affinity

Answer 19

D2: +++
muscarinic-cholinergic: ++
histamine: +++
serotonin: -