module 14 HRT estrogen

Question 1

oral estrogen MOA

Answer 1

absorbed from GI as estrone

• > converted to estrone sulfate in liver
• > continuously converted to estradiol, where concentrations remain steady

Question 2

oral estrogen use

Answer 2

HRT

Question 3

oral estrogen AE

Answer 3

inc. production of
- thyroxine binding globulin
- cortico-steroid binding globulin
- sex-hormone binding globulin
- TG, HDL
- clotting factors
VTE
Stroke

Question 4

oral estrogen Admin

Answer 4

significant 1st pass

once daily dosing

Question 5

preferred estrogen supplement route

Answer 5

transdermal

Question 6

transdermal estrogen use

Answer 6

HRT

• menopause s/s
• preserve bone density

Question 7

transdermal estrogen AE

Answer 7

VTE
stroke
inc. lipids
- less than oral

Question 8

transdermal estrogen EDU

Answer 8

administer with progestin in women with uterus

Question 9

vaginal estrogen use

Answer 9

low dose: vaginal atrophy

high dose: vasomotor s/s

Question 10

vaginal estrogen edu

Answer 10

no sex immediately after

Question 11

topical estradiol use

Answer 11

HRT

- vasomotor s/s

Question 12

topical estradiol AE

Answer 12

risk to children and pets

• nipple swelling
• breast development

Question 13

topical estradiol admin

Answer 13

lotion
gel
spray

Question 14

phytoestrogen: 3 major types

Answer 14

isoflavones
coumestans
lignans

Question 15

potent isoflavones:

Answer 15

soybean
chickpea
lentils

Question 16

potent lignans

Answer 16

flaxseed
lentils
grains
fruit
veggies