module 7 calcium channel blockers

Question 1

dihydropyridine

Answer 1

amlodipine 
felodinpine
nicardipine
nifedipine
nimodipine

Question 2

non-dihydropyridine

Answer 2

diltiazem
verapamil
- affect both cardiac and smooth muscle

Question 3

CCB mechanism of action

Answer 3

block Ca movement across calcium channels

-> vasodilation and dec. BP

Question 4

Non-dihydropyridine effects

Answer 4

dec. automaticity SA node (dec. HR)
dec. conduction to AV node
dec. afterload
dec. myocardial O2 demands
negative inotrope (dec. force of contraction)
inc. vasodilation of coronary arteries and peripheral arterioles
dec. BP

Question 5

dihydropyridine CCB site of action

Answer 5

greater affinity for Ca channels in vascular smooth muscle than cardiac muscle
- dec. BP

Question 6

dihydrophyridine CCB indication

Answer 6

HTN

preventing arterial spasm

Question 7

non-dihydropyridine CCB indication

Answer 7

atrial tachyarrhythmias
preventing arterial spasm
HTN

Question 8

verapamil

Answer 8

least selective CCB
effects on both cardiac and smooth muscle cells
additional uses: migraines and cluster headaches

Question 9

verapamil drug interactions

Answer 9

substrate and inhibitor of CYP3A4

- inhibits metabolism of other 3A4 drugs

Question 10

dihydrophyridine CCB adverse effects

Answer 10

headache
HypoTN
reflex tachycardia
dizziness
flushing 
peripheral edema

Question 11

non-dihydrophyridine CCB adverse effects

Answer 11

AV block
bradycardia 
worsening CHF (negative ionotropic)
headache 
HypoTN
conduction disturbances

Question 12

non-dihydropyridine CCB mechanism of action

Answer 12

blocks calcium entry at SA and AV node and cardiac arterial smooth muscle