module 13 PUD and GERD meds

Question 1

Drug classes that inhibit acid secretion

Answer 1

H2 antagonist
PPI
anticholinergics

Question 2

drug class that neutralizes gastric acid

Answer 2

antacids

Question 3

drug classes that protect gastric mucosa

Answer 3

sucralfate
colloidal bismuth
prostaglandins

Question 4

drugs that eradicate H.pylori

Answer 4

antibiotics

Question 5

H2 antagonist Rx

Answer 5

cimetidine
nizatidine
ranitidine
famotidine

Question 6

H2 antagonist MOA

Answer 6

competitive H2 Rc antagonist

-> suppress gastric acid secretion

Question 7

H2 antagonist AE

Answer 7

diarrhea/constipation
muscle pain
HA
fatigue
IV: confusion, hallucination

Question 8

H2 antagonist admin

Answer 8

peak: 1-3hr: works quick
renal excretion
hepatic metabolism

Question 9

H2 antagonist DI

Answer 9

drugs that require acidic mediums
cimetidine: inhibits: 3A4, 2D6, 1A2
HIV tx

Question 10

PPI meds

Answer 10

"-prazole"
rabeprazole
lansoprazole
pantoprazole
esomeprazole
omeprazole

Question 11

PPI MOA

Answer 11

block K/H/ATPase proton pump
- total shutdown of acid release (works late in cycle)
Covalent bond: irreverible

Question 12

PPI use

Answer 12

preferred tx for

• PUD
• hemorrhagic ulcer

Question 13

PPI AE

Answer 13

HA
GI disturbance
nausea
enteric infections
LT: unknown
- carcinoid tumers in animal studies

Question 14

PPI admin

Answer 14

rapid absorption
prodrug: converted in parietal cell canaliculus
short half life

Question 15

PPI precaution

Answer 15

crosses placenta

Question 16

PPI DI

Answer 16

metabolized by : 2C19, 3A4

inhibits: 2C19
- plavix

Question 17

anticholinergic med

Answer 17

dicyclomine

Question 18

anticholinergic MOA

Answer 18

muscarininc ACh Rc antagonist

-> dec. acid secretion

Question 19

dicyclomine AE

Answer 19

dry mouth
constipation
blurred vision
cardiac arrhythmia 
urinary retention

Question 20

dicyclomine edu

Answer 20

less effective than H2 antagonist and PPI

Question 21

antacid anions

Answer 21

carbonate
bicarb
citrate
phosphate
hydroxide

Question 22

antacid cations

Answer 22

Na
Mg
Ca
Al

Question 23

antacid MOA

Answer 23

neutralize acid

Question 24

antacid use

Answer 24

acute pain relief

- not tx of choice for PUD

Question 25

antacid AE

Answer 25

constipation: Al, Ca
diarrhea: Mg
electrolyte imbalance

Question 26

antacid Edu

Answer 26

antacid properties depend on the cation

- Na, Mg, Ca, Al