module 3 atypical antipsychotic

Question 1

clozapine

Answer 1

atypical antipsychotic

reserved for treatment-resistant patients

Question 2

clozapine AE

Answer 2

life threatening agranulocytosis
orthohypoTN
wt. gain
hyperglycemia
sedation
constipation

Question 3

clozapine DI

Answer 3

metabolized by 2D6, 3A4, 1A2

- smoking inc. metabolism

Question 4

clozapine monitoring

Answer 4

strict CBC

• weekly x 6mo
• biweekly x 6mo
• q4 weeks

Question 5

paliperidone

Answer 5

active metabolite of risperidone

Question 6

paliperidone AE

Answer 6

inc. prolactin
wt. gain
hyperglycemia
possible:
- sedation
- hypoTN
- EPS

Question 7

paliperidone administration

Answer 7

osmotic delivery capsule

- do not crush or chew

Question 8

paliperidone precaution

Answer 8

renally excreted

Question 9

Iloperidone AE

Answer 9

hypoTN

QT prolongation

Question 10

Illoperidone DI

Answer 10

CYP2D6

Question 11

aripiprazole MOA

Answer 11

partial D2 agonist
partial 5HT1a agonist
- reduced response
5HT2a, A1, H1 antagonist

Question 12

aripiprazole education

Answer 12

unpredictible levels of receptor activity

not used in combo with other antipsychotics

Question 13

aripiprazole AE

Answer 13

minimal

no wt, gain or hyperglycemia

Question 14

olanazapine AE

Answer 14

wt gain
hyperglycemia
possible: 
- anticholinergic
- sedation

Question 15

olanazapine administration

Answer 15

coated tablets
- if cut must use immediately 
ODT
PO
IM

Question 16

olanazapine DI

Answer 16

1A2: smoking inc. metabolism

Question 17

quetiapine use

Answer 17

low dose: sedation

Question 18

quetiapine AE

Answer 18

anticholinergic
wt gain
hyperglycemia
sedation
hypoTN

Question 19

quetiapine administration

Answer 19

wide dose range

- less interactions

Question 20

atypical antipsychotic formulations

Answer 20

all PO
ODT: aripiprazole, olanzapine, risperidone
IM: aripiprazole, olanzapine, ziprasidone
Depot: risperidone, paliperidone