module 4 opioid characteristics Flashcards
1
Q
opiate
A
naturally occurring drugs
- morphine
- codeine
2
Q
opioid
A
anything at acts like an opiate
- therapeutic agents
3
Q
mu 1 Rc
A
when agonized
- supraspinal analgesia
- bradycardia
- sedation
4
Q
mu 2 Rc
A
when agonized
- respiratory depression
- euphoria
- physical dependence
- dec. GI motility
- pupil constriction
5
Q
delta Rc
A
when agonized
- spinal analgesia
- respiratory depression
6
Q
K (kappa) Rc
A
when agonized
- spinal analgesia
- respiratory depression
- sedation
- dysphoria
- pupil constriction
7
Q
sigma Rc
A
dysphoria
delirium
hallucinations
pupil dilation
8
Q
Drugs that mainly act on Mu receptors, but some actions on other receptors
A
morphine
heroin
codeine
fentanyl
9
Q
agonist action at K receptors with partial antagonist action at mu receptors
A
pentazocine
10
Q
antagonists at mu, K, and sigma Rc
A
naloxone
naltrexone
11
Q
opioid characteristics
A
moderate to severe pain agonists vs. partial agonists vs. antagonists partial agonist: ceiling effect Hepatically metabolized tolerance and cross-tolerance
12
Q
physical tolerance
A
same dose has less effect
13
Q
full agonist drugs
A
morphine oxycodone hydromorphone methadone meperidine fetanyl oxymorphone codeine hydrocodone propoxyphene
14
Q
partial agonist and mixed agonist/antagonist drugs
A
pentazocine
butorphanol
nalbuphine
buprenorphine
15
Q
antagonist drug
A
naloxone
