module 7 adrenergic agonists

Question 1

sympathomimetics

Answer 1

drugs that mimic the natural function of the SNS

Question 2

sympathomimetic catecholamines

Answer 2

naturally occurring
epi
norpei
dopamine
dobutamine (synthetic)

Question 3

sympathomimetic non-catecholamines

Answer 3

phenylephrine
ephedrine
amphetamine

Question 4

epinephrine site of action and use

Answer 4

strong catecholamine
stimulates: B1, B2, a1
Uses: 
- anaphylaxis
- improve CO
- bradycardia
- advanced cardiac life support
- refectory hypoTN

Question 5

Epi dosing

Answer 5

lower doses: 
- B2 -> bronchial smooth muscle dilation 
increased dose: 
- B1: -> inc. CO, contractility, BP, HR
- a1: -> vasoconstriction

Question 6

epi adverse effects

Answer 6

hyperglycemia (gluconeogenesis)
metabolic acidosis
atrial and ventricular arrhythmia

Question 7

norepi site of action and use

Answer 7

a receptors: vasoconstrictor -> inc. SVR
b receptors: positive inotrope (inc. force of contraction)
uses: 
- significant hypoTN
- impaired CO

Question 8

norepi caution

Answer 8

inc. myocardial oxygen demand

end-organ damage due to vasoconstriction

Question 9

dopamine site of action and uses

Answer 9

stimulates domapinergic, B, and a receptors

uses:
- hypoTN
- heart failure
- cardiogenic shock

Question 10

dopamine doses

Answer 10

lower doses: strong B effect

higher doses: strong alpha effect

Question 11

dopamine adverse effects

Answer 11

tachycardia
atrial and ventricular arrhythmia
limb and end organ ischemia

Question 12

dobutamine mechanism of action

Answer 12

improves CO by stimulating B1 -> inc. HR and contractility

Question 13

dobutamine indication

Answer 13

decompensated HF

Question 14

dobutamine adverse effects

Answer 14

tachycardia
arrhythmia
hypoTN