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Pharmacology > module 3 MAOI, SSRI, TCA > Flashcards

module 3 MAOI, SSRI, TCA Flashcards

1
Q

MAOI MOA

A

inhibits degradation of monoamines

-> inc. serotonin and norepi in synapse

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2
Q

MAOI AE

A

tyramine toxicity d/t GI and hepatic MAOI

  • > displacement of chatecholamines
  • > HTN crisis
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3
Q

MAOI precautions

A

hepatically metabolized

renaly excreted

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4
Q

MAOI interactions

A 
CYP450
TCA
SSRI
pseudoephedrine
dextromethorphan
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5
Q

MAOI administration

A

PO: tyramine diet restrictions
transdermal: avoids 1st pass, less tyramine sensitivity.

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6
Q

non-selective irreversible MAOI drugs

A

phenelzine

isocarboxazid

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7
Q

non-selective reversible MAOI drugs

A

tranylcypromine

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8
Q

selective reversible MAO-AI drugs

A

meclobemide
befloxatone
brofaromine

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9
Q

irreversible MAO-B drugs

A

selegiline
rasasgiline
- dopamine

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10
Q

TCA: reuptake inhibitors MOA

A

antagonize 5HT and Norepi reupatke transporter -> inc. serotonin and norepi

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11
Q

TCA use

A

depression

neuropathic pain

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12
Q

TCA AE

A 
first degree heart block 
bundle branch block
anticholinergic: antagonize muscarinic
antagonize histamine: 
- sedation 
- wt. gain
- confusion 
antagonize adrenergic: 
- ortho hypoTN
- reflex tachycardia
- drowsiness
- dizzy
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13
Q

TCA interactions

A

CYP450

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14
Q

TCA secondary amine drugs

A

NE > 5HT

  • nortriptyline
  • despiramine
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15
Q

TCA tertiary amine drugs

A

5HT > NT

  • amitriptyline
  • imipramine
  • doxepin
  • clomipramine
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16
Q

SSRI drugs

A 
fluoxetine
citalopram
fluvoxamine
parosetine
excitalopram
17
Q

SSRI MOA

A

selective for 5HT transporters

-> inc. 5HT in synapse

18
Q

SSRI AE

A 
sexual dysfunction 
serotonin syndrome
- hyperthermia
- muscle rigidity
- myoclonus
- mental status fluctuations
- vital fluctuations
19
Q

SSRI educations

A

first line
- highly selcetive, less AE
Low selectivity at high doses

Pharmacology (78 decks)

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