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Pharmacology > module 16 phosphate binders, Ca, Vit. D > Flashcards

module 16 phosphate binders, Ca, Vit. D Flashcards

1
Q

oral phosphate binder meds

A

calcium carbonate
calcium acetate
selvelamer

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2
Q

calcium carbonate/acetate MOA

A

binds to dietary phosphate preventing absorption

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3
Q

calcium carbonate/acetate use

A

CKD related hyperparathyroidism

hypocalcemia

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4
Q

calcium carbonate/acetate AE

A

iatrogenic hypercalcemia

  • inc. risk with Vit. D supplementation
    inc. vascular calcification risk
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5
Q

calcium carbonate/acetate admin

A

with meals

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6
Q

calcium carbonate/acetate monitoring

A

Ca

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7
Q

sevelamer MOA

A

binds to dietary phosphate preventing absorption

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8
Q

sevelamer use

A

CKD related hyperparathyroidism

hypercalcemia

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9
Q

sevelamer AE

A

sevelamer HCL: dec bicarb -> metabolic acidosis

sevelamer carbonate: buffered to avoid metabolic acidosis

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10
Q

sevelamer EDU

A

also binds bile acid -> dec. cholesterol

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11
Q

lanthanum carbonate MOA

A

rare earth element with high phosphate binding

-> inhibits dietary absorption

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12
Q

lanthanum carbonate use

A

CKD related hyperparathyroidism

hypercalcemia

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13
Q

vitamin D and analog meds

A

calcitriol
doxecalciferol
paricalcitol

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14
Q

paricalcitol

A

synthetic analog of Vit. D

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15
Q

doxecalciferol

A

activated in liver

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16
Q

Vitamin D and analogs use

A

CKD related hyperparathyroidism

17
Q

vitamin D and analog AE

A

hypercalcemia

18
Q

calcimimetic med

A

cinacalcet

19
Q

cinacalcet MOA

A

binds to Ca sensing Rc

  • > inc. sensitivity to Ca
  • > activation at lower Ca level
  • > dec. PTH synthesis and secretion
20
Q

cinacalcet use

A

secondary hyperparathyroidism

hypercalcemia r/t parathyroid carcinoma

21
Q

calcium meds

A 
IV: 
- Ca gluconate
- Ca chloride
Oral:
- Ca citrate
- Ca carbonate
- Ca phosphate
- Ca lactate
22
Q

calcium use

A

IV: severe hypocalcemia

oral:
- hypoparathyroidism
- osteoporosis

23
Q

calcium admin

A 
Ca citrate: best absorbed
Ca carbonate: 
- low cost
- antacid properties
- absorbed best with food
24
Q

calcium AE

A

constipation

kidney stones

25
Q

Vitamin D meds

A

cholecalciferol D3

Ergocalciferol D2

26
Q

Vitamin D use

A

hypoparathyroidism
rickets
osteomalacia
osteoporosis

27
Q

vitamin D EDU

A

not active form has to be converted by kidney

  • cholecalciferol
  • ergocalciferol

Pharmacology (78 decks)

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