Module 3 anti-migraine Flashcards
1
Q
Migraine patho
A
cerebral vasodilation with activation of pain fibers
2
Q
triptans MOA
A
5HT 1B/1D agonists in vasculature
- > potent vasoconstriction of intracranial blood vessels
- inhibit vasoactive peptides
- interruption of pain signal transmission
3
Q
triptans drugs
A
sumatriptan rizatriptan almotrptan frovatriptan eletripatn zolmitriptan naratriptan
4
Q
Triptan with slowest onset
A
naratriptan
5
Q
triptan with lowest recurrence
A
naratriptan
6
Q
triptan with fastest onset
A
riztriptan
7
Q
triptans administration
A
PO orally disintegrating tablets SubQ nasal suppository
8
Q
triptans use
A
migraines
- acute attack
9
Q
triptans contra
A
ischemic heart disease HTN ischemic stroke pregnancy MAOI: metabolized by MAO SSRI, SNRI: risk of serotonin syndrome eletriptan: CYP3A4
10
Q
Ergot drugs
A
ergotamine
dihydroergotamine (DHE45)
11
Q
ergot MOA
A
5ht 1B/!D agonist
12
Q
ergot use
A
migraines >48hr
- not used often d/t AE
13
Q
ergotamine AE
A
worsening N/V
dose assoc. vascular occlusion
rebound HA
14
Q
DHE45 AE
A
fewer
- use with antiemetic
15
Q
ergotamine contra
A
CAD PVD HTN hepatic disease renal disease
