module 16 osteoporosis overview

Question 1

osteoblasts

Answer 1

anabolic activity

build bone

Question 2

osteoclasts

Answer 2

catabolic activity

breakdown bone

Question 3

osteocytes

Answer 3

storage of Ca and bone repair

Question 4

glucocorticoid induced osteroporosis

Answer 4

inhibit osteoblast activity
stimulate osteoclasts
dec. GI absorption of calcium
inc. Ca excretion in kidneys

Question 5

glucocorticoid and preventative therapy

Answer 5

Ca/Vit D
bisphosphonates
lifestyle modification: wt training

Question 6

PTH

Answer 6

modulates bone resorption and stimulates tubular resorption of Ca
- inc. Ca levels

Question 7

High Ca and PTH

Answer 7

high Ca suppresses PTH secretion

Question 8

low Ca and PTH

Answer 8

low Ca stimulates PTH secretion

Question 9

cholecalciferol

Answer 9

Vit D3

- absorbed via skin

Question 10

ergocalciferol

Answer 10

Vit D2

- food source

Question 11

Vit D converted in liver

Answer 11

to 25-hydroxy Vit D

Question 12

Vit D converted in kidney

Answer 12

to 1,25 dihydroxy Vit D

- active form

Question 13

calcitonin

Answer 13

opposite of PTH
- dec. bone reabsorption
- dec. plasma Ca levels
Binds to Rc of osteoclasts and inhibits activity

Question 14

CKD and osteoporosis

Answer 14

secondary hyperparathyroidism
- hypocalcemia, hyperphosphatemia, dec. calcitriol production
Enhances bone reabsorption