module 13 GERD meds 2 Flashcards

1
Q

sucralfate MOA

A

complex salt of sucrose sulfate and Al hydroxide
- creates gel that binds to + proteins and sticks to ulcer
-> protects tissue from aggressive factors
No change to gastric pH

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2
Q

sucralfate use

A

PUD symptomatic relief

protectant

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3
Q

sucralfate AE

A

constipation

little systemic absorption

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4
Q

sucralfate admin

A

large tablets

freq. admin

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5
Q

sucralfate DI

A

binds to other drugs

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6
Q

Colloidal bismuth MOA

A

coating agent/ barrier formation

  • protects mucosa
  • stimulates mucosal HCO3 and PGE2
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7
Q

collodial bismuth use

A

PUD: protectant

impede H. pylori growth

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8
Q

progtaglandin med

A

misoprostol

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9
Q

misoprostol MOA

A

PG analog

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10
Q

misoprostol use

A

prevent NSAID induced PUD

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11
Q

misoprostol AE

A

adb. discomfort

diarrhea

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12
Q

misoprostol CI

A

pregnancy

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13
Q

Tx of H. pylori triple therapy

A

amoxicillin
clarithromycin
PPI

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14
Q

Tx of H. pylori quad therapy

A
tetracycline
metronidazole
PPI
bismuth 
- used with PCN allergy or failed triple therapy
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15
Q

Tx of GERD

A

preferred: PPI
- raise gastric pH for long period
other:
- H2 antagonist
- antacids
- suralfate
- metoclopramide: enhances emptying, inc. lower esophageal tone

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16
Q

Modification of risk factors

A

avoid caffeine
avoid ETOH
stop smoking
avoid NSAIDS