module 13 GERD meds 2 Flashcards
sucralfate MOA
complex salt of sucrose sulfate and Al hydroxide
- creates gel that binds to + proteins and sticks to ulcer
-> protects tissue from aggressive factors
No change to gastric pH
sucralfate use
PUD symptomatic relief
protectant
sucralfate AE
constipation
little systemic absorption
sucralfate admin
large tablets
freq. admin
sucralfate DI
binds to other drugs
Colloidal bismuth MOA
coating agent/ barrier formation
- protects mucosa
- stimulates mucosal HCO3 and PGE2
collodial bismuth use
PUD: protectant
impede H. pylori growth
progtaglandin med
misoprostol
misoprostol MOA
PG analog
misoprostol use
prevent NSAID induced PUD
misoprostol AE
adb. discomfort
diarrhea
misoprostol CI
pregnancy
Tx of H. pylori triple therapy
amoxicillin
clarithromycin
PPI
Tx of H. pylori quad therapy
tetracycline metronidazole PPI bismuth - used with PCN allergy or failed triple therapy
Tx of GERD
preferred: PPI
- raise gastric pH for long period
other:
- H2 antagonist
- antacids
- suralfate
- metoclopramide: enhances emptying, inc. lower esophageal tone